Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

B Wang, L Wu, J Chen, L Dong, C Chen… - Signal transduction and …, 2021 - nature.com
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology,
carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified …

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

D Panigrahy, MM Gilligan, S Huang, A Gartung… - Cancer and metastasis …, 2020 - Springer
Abstract Severe coronavirus disease (COVID-19) is characterized by pulmonary hyper-
inflammation and potentially life-threatening “cytokine storms”. Controlling the local and …

Carcinogenesis: Failure of resolution of inflammation?

A Fishbein, BD Hammock, CN Serhan… - Pharmacology & …, 2021 - Elsevier
Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

[HTML][HTML] Eicosanoids: the overlooked storm in coronavirus disease 2019 (COVID-19)?

BD Hammock, W Wang, MM Gilligan… - The American journal of …, 2020 - Elsevier
Severe coronavirus disease 2019 (COVID-19) symptoms, including systemic inflammatory
response and multisystem organ failure, are now affecting thousands of infected patients …

The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives

L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Movement to the clinic of soluble epoxide hydrolase inhibitor EC5026 as an analgesic for neuropathic pain and for use as a nonaddictive opioid alternative

BD Hammock, CB McReynolds, K Wagner… - Journal of medicinal …, 2021 - ACS Publications
This report describes the development of an orally active analgesic that resolves
inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts …

Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health

C Morisseau, BD Hammock - Annual review of pharmacology …, 2013 - annualreviews.org
The presence of epoxyeicosatrienoic acids (EETs) in tissues and their metabolism by
soluble epoxide hydrolase (sEH) to 1, 2-diols were first reported 30 years ago. However …

Mass spectrometry‐based metabolomics

K Dettmer, PA Aronov… - Mass spectrometry …, 2007 - Wiley Online Library
This review presents an overview of the dynamically developing field of mass spectrometry‐
based metabolomics. Metabolomics aims at the comprehensive and quantitative analysis of …

Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases

KM Wagner, CB McReynolds, WK Schmidt… - Pharmacology & …, 2017 - Elsevier
Eicosanoids are biologically active lipid signaling molecules derived from polyunsaturated
fatty acids. Many of the actions of eicosanoid metabolites formed by cyclooxygenase and …

Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases

JD Imig, BD Hammock - Nature reviews Drug discovery, 2009 - nature.com
The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …