Sex differences in the biology of different organ systems and the influence of sex hormones
in modulating health and disease are increasingly relevant in clinical and research areas …

Introduction: Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe
asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma …

Background Dupilumab is a fully human anti–interleukin-4 receptor α monoclonal antibody
that blocks both interleukin-4 and interleukin-13 signaling. We assessed its efficacy and …

Objective: This study sought to characterize the epidemiologic, clinical, humanistic, and
economic burden of patients with asthma uncontrolled by GINA Steps 4 or 5 treatment …

Background: The severe asthma and severe, uncontrolled asthma (SUA) populations in
Japan are not well-studied. We investigated the prevalence of continuously treated severe …

Patients with uncontrolled severe persistent asthma have greater morbidity, greater use of
health care resources, and more impairment in health-related quality of life when compared …

Objective: We aimed to perform a meta-analysis evaluating the efficacy and safety of
dupilumab in patients with uncontrolled asthma. Data source: A search of electronic …

A major burden of severe asthma is the future risk of adverse health outcomes. Patients with
severe asthma are prone to serious exacerbation and deterioration of lung function and may …

Background Dupilumab blocks the shared receptor component for interleukin (IL)‐4/IL‐13,
key drivers of type 2 inflammation. In phase 2b (NCT01854047) and phase 3 LIBERTY …

Background Dupilumab, a fully human monoclonal antibody, blocks the shared receptor
component for interleukin-4 and interleukin-13, key drivers of type 2 inflammation. In the …