Mendelian randomization

E Sanderson, MM Glymour, MV Holmes… - Nature Reviews …, 2022 - nature.com
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

Mendelian randomization: concepts and scope

RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

VW Skrivankova, RC Richmond, BAR Woolf… - bmj, 2021 - bmj.com
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …

Objectives, design and main findings until 2020 from the Rotterdam Study

MA Ikram, G Brusselle, M Ghanbari… - European journal of …, 2020 - Springer
Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

AR Carter, E Sanderson, G Hammerton… - European journal of …, 2021 - Springer
Mediation analysis seeks to explain the pathway (s) through which an exposure affects an
outcome. Traditional, non-instrumental variable methods for mediation analysis experience …

Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: a Mendelian randomization analysis …

S Rao, A Lau, HC So - Diabetes care, 2020 - Am Diabetes Assoc
OBJECTIVE COVID-19 has become a major public health problem. There is good evidence
that ACE2 is a receptor for SARS-CoV-2, and high expression of ACE2 may increase …

Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank

S Ai, J Zhang, G Zhao, N Wang, G Li… - European Heart …, 2021 - academic.oup.com
Aims Observational studies have suggested strong associations between sleep duration
and many cardiovascular diseases (CVDs), but causal inferences have not been confirmed …

Type 2 diabetes and cancer: an umbrella review of observational and mendelian randomization studies

J Pearson-Stuttard, N Papadimitriou… - … Biomarkers & Prevention, 2021 - AACR
Background: Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of
developing several common cancers, but it is unclear whether this association is causal. We …

Sleep duration and myocardial infarction

I Daghlas, HS Dashti, J Lane, KG Aragam… - Journal of the American …, 2019 - jacc.org
Background: Observational studies suggest associations between extremes of sleep
duration and myocardial infarction (MI), but the causal contribution of sleep to MI and its …

Gastrointestinal consequences of type 2 diabetes mellitus and impaired glycemic homeostasis: a mendelian randomization study

J Chen, S Yuan, T Fu, X Ruan, J Qiao, X Wang… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE We conducted a Mendelian randomization (MR) study to examine the
associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs) …