Mendelian randomization
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …
address causal questions about how modifiable exposures influence different outcomes …
Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration
VW Skrivankova, RC Richmond, BAR Woolf… - bmj, 2021 - bmj.com
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …
modifiable exposures on health outcomes, but the published evidence is often hampered by …
Objectives, design and main findings until 2020 from the Rotterdam Study
MA Ikram, G Brusselle, M Ghanbari… - European journal of …, 2020 - Springer
Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …
Mendelian randomisation for mediation analysis: current methods and challenges for implementation
Mediation analysis seeks to explain the pathway (s) through which an exposure affects an
outcome. Traditional, non-instrumental variable methods for mediation analysis experience …
outcome. Traditional, non-instrumental variable methods for mediation analysis experience …
Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: a Mendelian randomization analysis …
OBJECTIVE COVID-19 has become a major public health problem. There is good evidence
that ACE2 is a receptor for SARS-CoV-2, and high expression of ACE2 may increase …
that ACE2 is a receptor for SARS-CoV-2, and high expression of ACE2 may increase …
Causal associations of short and long sleep durations with 12 cardiovascular diseases: linear and nonlinear Mendelian randomization analyses in UK Biobank
Aims Observational studies have suggested strong associations between sleep duration
and many cardiovascular diseases (CVDs), but causal inferences have not been confirmed …
and many cardiovascular diseases (CVDs), but causal inferences have not been confirmed …
Type 2 diabetes and cancer: an umbrella review of observational and mendelian randomization studies
J Pearson-Stuttard, N Papadimitriou… - … Biomarkers & Prevention, 2021 - AACR
Background: Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of
developing several common cancers, but it is unclear whether this association is causal. We …
developing several common cancers, but it is unclear whether this association is causal. We …
Sleep duration and myocardial infarction
Background: Observational studies suggest associations between extremes of sleep
duration and myocardial infarction (MI), but the causal contribution of sleep to MI and its …
duration and myocardial infarction (MI), but the causal contribution of sleep to MI and its …
Gastrointestinal consequences of type 2 diabetes mellitus and impaired glycemic homeostasis: a mendelian randomization study
OBJECTIVE We conducted a Mendelian randomization (MR) study to examine the
associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs) …
associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs) …