Advances in ionisation techniques for mass spectrometry‐based omics research

B Challen, R Cramer - Proteomics, 2022 - Wiley Online Library
Omics analysis by mass spectrometry (MS) is a vast field, with proteomics, metabolomics
and lipidomics dominating recent research by exploiting biological MS ionisation …

Acoustic ejection mass spectrometry: a fully automatable technology for high-throughput screening in drug discovery

RP Simon, TT Häbe, R Ries, M Winter… - … the Science of Drug …, 2021 - journals.sagepub.com
Acoustic droplet ejection (ADE)–open port interface (OPI)–mass spectrometry (MS) has
recently been introduced as a versatile analytical method that combines fast and contactless …

High-throughput intact protein analysis for drug discovery using infrared matrix-assisted laser desorption electrospray ionization mass spectrometry

F Pu, SA Ugrin, AJ Radosevich, D Chang-Yen… - Analytical …, 2022 - ACS Publications
Mass spectrometry (MS) is the primary analytical tool used to characterize proteins within the
biopharmaceutical industry. Electrospray ionization (ESI) coupled to liquid chromatography …

Ultra-high-throughput ambient MS: direct analysis at 22 samples per second by infrared matrix-assisted laser desorption electrospray ionization mass spectrometry

AJ Radosevich, F Pu, D Chang-Yen… - Analytical …, 2022 - ACS Publications
Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass
spectrometry is an ambient-direct sampling method that is being developed for high …

Direct analysis from phase-separated liquid samples using ADE-OPI-MS: applicability to high-throughput screening for inhibitors of diacylglycerol acyltransferase 2

X Wen, C Liu, L Ghislain, K Tovar, V Shah… - Analytical …, 2021 - ACS Publications
The primary goal of high-throughput screening (HTS) is to rapidly survey a broad collection
of compounds, numbering from tens of thousands to millions of members, and identify those …

Data processing for high-throughput mass spectrometry in drug discovery

C Liu, H Zhang - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction High-throughput mass spectrometry that could deliver> 10 times faster sample
readout speed than traditional LC-based platforms has emerged as a powerful analytical …

Acoustic mist ionization mass spectrometry for ultrahigh-throughput metabolomics screening

MJ Smith, DP Ivanov, RJM Weber, J Wingfield… - Analytical …, 2021 - ACS Publications
Incorporating safety data early in the drug discovery pipeline is key to reducing costly lead
candidate failures. For a single drug development project, we estimate that several thousand …

[HTML][HTML] Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice

M Winter, RP Simon, TT Häbe, R Ries, Y Wang… - SLAS Discovery, 2023 - Elsevier
Acoustic droplet ejection-open port interface-mass spectrometry (ADE-OPI-MS) is a novel
label-free analytical technique, promising to become a versatile readout for high-throughput …

Acoustic Sampling for Mass Spectrometry: Fundamentals and Applications in High‐Throughput Drug Discovery

C Liu, L Ghislain, J Wingfield… - … Mass Spectrometry in …, 2023 - Wiley Online Library
Mass spectrometry (MS) has become one of the primary analytical platforms in drug
discovery to deliver high‐fidelity, label‐free analysis results. However, sample introduction …

[图书][B] Advanced ultrasonic ambient ionisation sources for mass spectrometry and microdroplet accelerated reactions

HJ Taylor - 2022 - search.proquest.com
Advanced Ultrasonic Ambient Ionisation Sources for Mass Spectrometry and Microdroplet
Accelerated Reactions Harry James Taylor Page 1 Advanced Ultrasonic Ambient Ionisation …