Comprehensive analysis of DNA methylation data with RnBeads
RnBeads is a software tool for large-scale analysis and interpretation of DNA methylation
data, providing a user-friendly analysis workflow that yields detailed hypertext reports …
data, providing a user-friendly analysis workflow that yields detailed hypertext reports …
Long-range interactions between topologically associating domains shape the four-dimensional genome during differentiation
Genomic information is selectively used to direct spatial and temporal gene expression
during differentiation. Interactions between topologically associating domains (TADs) and …
during differentiation. Interactions between topologically associating domains (TADs) and …
Ancestral perinatal obesogen exposure results in a transgenerational thrifty phenotype in mice
R Chamorro-Garcia, C Diaz-Castillo… - Nature …, 2017 - nature.com
Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed
descendants. This transgenerational inheritance has significant implications for …
descendants. This transgenerational inheritance has significant implications for …
The draft genome of blunt snout bream (Megalobrama amblycephala) reveals the development of intermuscular bone and adaptation to herbivorous diet
H Liu, C Chen, Z Gao, J Min, Y Gu, J Jian, X Jiang… - …, 2017 - academic.oup.com
The blunt snout bream Megalobrama amblycephala is the economically most important
cyprinid fish species. As an herbivore, it can be grown by eco-friendly and resource …
cyprinid fish species. As an herbivore, it can be grown by eco-friendly and resource …
Substantial loss of conserved and gain of novel microRNA families in flatworms
Recent studies on microRNA (miRNA) evolution focused mainly on the comparison of
miRNA complements between animal clades. However, evolution of miRNAs within such …
miRNA complements between animal clades. However, evolution of miRNAs within such …
Uracil accumulation and mutagenesis dominated by cytosine deamination in CpG dinucleotides in mice lacking UNG and SMUG1
L Alsøe, A Sarno, S Carracedo, D Domanska… - Scientific reports, 2017 - nature.com
Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed
by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single …
by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single …
ATRX binds to atypical chromatin domains at the 3′ exons of zinc finger genes to preserve H3K9me3 enrichment
D Valle-García, ZA Qadeer, DS McHugh… - Epigenetics, 2016 - Taylor & Francis
ABSTRACT ATRX is a SWI/SNF chromatin remodeler proposed to govern genomic stability
through the regulation of repetitive sequences, such as rDNA, retrotransposons, and …
through the regulation of repetitive sequences, such as rDNA, retrotransposons, and …
EBNA2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin D receptor occupancy
Epstein-Barr virus (EBV) is a non-heritable factor that associates with multiple sclerosis
(MS). However its causal relationship with the disease is still unclear. The virus establishes …
(MS). However its causal relationship with the disease is still unclear. The virus establishes …
glbase: a framework for combining, analyzing and displaying heterogeneous genomic and high-throughput sequencing data
Genomic datasets and the tools to analyze them have proliferated at an astonishing rate.
However, such tools are often poorly integrated with each other: each program typically …
However, such tools are often poorly integrated with each other: each program typically …
Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage
J Madsen-Østerbye, M Abdelhalim, MO Baudement… - Genome Biology, 2022 - Springer
Background Interactions of chromatin with the nuclear lamina via lamina-associated
domains (LADs) confer structural stability to the genome. The dynamics of positioning of …
domains (LADs) confer structural stability to the genome. The dynamics of positioning of …