Oxidation of amine α-carbon to amide: a review on direct methods to access the amide functionality
P Nagaraaj, V Vijayakumar - Organic Chemistry Frontiers, 2019 - pubs.rsc.org
A number of methods have been adopted for the synthesis of amides; among these
methods, the oxidation of an amine to an amide is growing in interest as a means to prepare …
methods, the oxidation of an amine to an amide is growing in interest as a means to prepare …
Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles
The Schmidt reaction has been an efficient and widely used synthetic approach to amides
and nitriles since its discovery in 1923. However, its application often entails the use of …
and nitriles since its discovery in 1923. However, its application often entails the use of …
Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C–N Cleavage of N,N-Dibenzylanilines
N Neerathilingam, M Bhargava Reddy… - The Journal of Organic …, 2021 - ACS Publications
A visible-light-driven photoredox-catalyzed nonaqueous oxidative C–N cleavage of N, N-
dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2 …
dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2 …
Visible‐Light‐Induced Oxidation of Diazenyl‐Protected Tetrahydroisoquinolines and Isoindolines for the Synthesis of Functionalized Lactams
A visible‐light‐induced oxidation of diazenyl‐protected tetrahydroisoquinolines and
isoindolines for the synthesis of structurally diverse lactams is developed. The reaction was …
isoindolines for the synthesis of structurally diverse lactams is developed. The reaction was …
Recent Advances in Synthesis of 3,4‐Dihydroisoquinolin‐1(2H)‐one
MR Kulkarni, ND Gaikwad - ChemistrySelect, 2020 - Wiley Online Library
Abstract The 3, 4‐dihydroisoquinolin‐1 (2H)‐one motifs found in many natural products,
synthetic molecules with a diverse range of the biological activities and represent a privilege …
synthetic molecules with a diverse range of the biological activities and represent a privilege …
Isoindolinone synthesis: selective dioxane-mediated aerobic oxidation of isoindolines
N-Alkyl and N-aryl-isoindolinones were prepared by a dioxane-mediated oxidation of
isoindoline precursors. The transformation exhibits unique chemoselectivity for …
isoindoline precursors. The transformation exhibits unique chemoselectivity for …
Ionic liquid catalysed aerobic oxidative amidation and thioamidation of benzylic amines under neat conditions
Tetrabutylammonium hydroxide (TBAOH) was discovered as a highly efficient and green
catalyst for aerobic oxidation of the α-methylene carbon of primary amines as well as …
catalyst for aerobic oxidation of the α-methylene carbon of primary amines as well as …
Metal free C–H functionalization enabled diastereoselective multicomponent reaction of N-heterocycles to fused heteropolycycles
A novel C–H functionalization enabled multicomponent reaction involving N-heterocycles,
dinucleophile, and dipolarophile has been developed. Direct α-and more challenging β-C …
dinucleophile, and dipolarophile has been developed. Direct α-and more challenging β-C …
Base-Promoted Tandem Synthesis of 3, 4-Dihydroisoquinolones
Using benzaldehydes, NaN (SiMe3) 2, and N-acylpyrroles, an operationally simple tandem
method to produce a wide array of 3, 4-dihydroisoquinolones is presented (37 examples …
method to produce a wide array of 3, 4-dihydroisoquinolones is presented (37 examples …
Selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the ring contraction and deformylative functionalization of piperidine derivatives
F Wang, X Zhang, Y He, X Fan - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
In this paper, a selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the cascade
reactions of N-substituted piperidines is presented. Mechanistically, the formation of …
reactions of N-substituted piperidines is presented. Mechanistically, the formation of …