Oxidation of amine α-carbon to amide: a review on direct methods to access the amide functionality

P Nagaraaj, V Vijayakumar - Organic Chemistry Frontiers, 2019 - pubs.rsc.org
A number of methods have been adopted for the synthesis of amides; among these
methods, the oxidation of an amine to an amide is growing in interest as a means to prepare …

Nitromethane as a nitrogen donor in Schmidt-type formation of amides and nitriles

J Liu, C Zhang, Z Zhang, X Wen, X Dou, J Wei, X Qiu… - Science, 2020 - science.org
The Schmidt reaction has been an efficient and widely used synthetic approach to amides
and nitriles since its discovery in 1923. However, its application often entails the use of …

Regioselective Synthesis of 2° Amides Using Visible-Light-Induced Photoredox-Catalyzed Nonaqueous Oxidative C–N Cleavage of N,N-Dibenzylanilines

N Neerathilingam, M Bhargava Reddy… - The Journal of Organic …, 2021 - ACS Publications
A visible-light-driven photoredox-catalyzed nonaqueous oxidative C–N cleavage of N, N-
dibenzylanilines to 2° amides is reported. Further, we have applied this protocol on 2 …

Visible‐Light‐Induced Oxidation of Diazenyl‐Protected Tetrahydroisoquinolines and Isoindolines for the Synthesis of Functionalized Lactams

T Zhang, Y Wang, B Wang, W Jin, Y Xia… - Advanced Synthesis …, 2022 - Wiley Online Library
A visible‐light‐induced oxidation of diazenyl‐protected tetrahydroisoquinolines and
isoindolines for the synthesis of structurally diverse lactams is developed. The reaction was …

Recent Advances in Synthesis of 3,4‐Dihydroisoquinolin‐1(2H)‐one

MR Kulkarni, ND Gaikwad - ChemistrySelect, 2020 - Wiley Online Library
Abstract The 3, 4‐dihydroisoquinolin‐1 (2H)‐one motifs found in many natural products,
synthetic molecules with a diverse range of the biological activities and represent a privilege …

Isoindolinone synthesis: selective dioxane-mediated aerobic oxidation of isoindolines

P Thapa, E Corral, S Sardar, BS Pierce… - The Journal of Organic …, 2018 - ACS Publications
N-Alkyl and N-aryl-isoindolinones were prepared by a dioxane-mediated oxidation of
isoindoline precursors. The transformation exhibits unique chemoselectivity for …

Ionic liquid catalysed aerobic oxidative amidation and thioamidation of benzylic amines under neat conditions

A Joshi, R Kumar, R Semwal, D Rawat… - Green Chemistry, 2019 - pubs.rsc.org
Tetrabutylammonium hydroxide (TBAOH) was discovered as a highly efficient and green
catalyst for aerobic oxidation of the α-methylene carbon of primary amines as well as …

Metal free C–H functionalization enabled diastereoselective multicomponent reaction of N-heterocycles to fused heteropolycycles

S Mandal, S Dwari, CK Jana - The Journal of Organic Chemistry, 2018 - ACS Publications
A novel C–H functionalization enabled multicomponent reaction involving N-heterocycles,
dinucleophile, and dipolarophile has been developed. Direct α-and more challenging β-C …

Base-Promoted Tandem Synthesis of 3, 4-Dihydroisoquinolones

J Li, H Wang, H Jin, Z Xiang, L Chen, PJ Walsh… - Organic …, 2022 - ACS Publications
Using benzaldehydes, NaN (SiMe3) 2, and N-acylpyrroles, an operationally simple tandem
method to produce a wide array of 3, 4-dihydroisoquinolones is presented (37 examples …

Selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the ring contraction and deformylative functionalization of piperidine derivatives

F Wang, X Zhang, Y He, X Fan - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
In this paper, a selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the cascade
reactions of N-substituted piperidines is presented. Mechanistically, the formation of …