Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy.
Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic …

Background: The imbalance of angiogenic regulators in tumors drives tumor angiogenesis
and causes the vasculature to develop much differently in tumors than in normal tissue …

In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the
interactions of tumor cells with their microenvironment. Recent technological advances in …

Despite the increasing use of stereotactic body radiation therapy (SBRT) and stereotactic
radiation surgery (SRS) in recent years, the biological base of these high-dose hypo …

Simple Summary Stereotactic ablative radiotherapy (SABR), which irradiates tumors with
high-dose radiation per fraction, promotes anti-tumor immunity by stimulating various …

Stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT) represent non-
invasive, efficacious and safe radiation treatments for the ablation of intracranial and …

Sunitinib malate is a small multi‐targeted tyrosine kinase inhibitor that inhibits vascular
endothelial growth factor receptor (VEGFR), platelet‐derived growth factor receptor …

Radiation therapy (RT) causes DNA damage through ionization, leading to double-strand
breaks. In addition, it generates reactive oxygen species (ROS), which are toxic to tumor …

Cellular invasion into local tissues is a process important in development and homeostasis.
Malregulated invasion and subsequent cell movement is characteristic of multiple …

Background Tumor endothelial marker 1 (TEM1) is a protein expressed in the tumor-
associated endothelium and/or stroma of various types of cancer. We previously …