A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis

WW Lautt - Journal of pharmacological sciences, 2004 - jstage.jst.go.jp
The glucose disposal effect of insulin after a meal is accounted for in approximately equal
measure by the direct action of insulin and the action of HISS (hepatic insulin sensitizing …

Insulin resistance induced by sucrose feeding in rats is due to an impairment of the hepatic parasympathetic nerves

RT Ribeiro, WW Lautt, DJ Legare, MP Macedo - Diabetologia, 2005 - Springer
Aims/hypothesis A considerable proportion of whole-body insulin-stimulated glucose uptake
is dependent upon the hepatic insulin-sensitising substance (HISS) in a pathway mediated …

Practice and principles of pharmacodynamic determination of HISS‐dependent and HISS‐independent insulin action: Methods to quantitate mechanisms of insulin …

WW Lautt - Medicinal research reviews, 2003 - Wiley Online Library
Injection of insulin causes release of HISS (hepatic insulin sensitizing substance) from the
liver in the fed state. HISS action accounts for 50–60% of the glucose disposal produced by …

Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver

MP Guarino, NC Correia, WW Lautt… - American Journal of …, 2004 - journals.physiology.org
The hepatic parasympathetic nerves and hepatic nitric oxide synthase (NOS) are involved in
the secretion of a hepatic insulin sensitizing substance (HISS), which mediates peripheral …

Insulin sensitivity in skeletal muscle regulated by a hepatic hormone, HISS

WW Lautt - Canadian journal of applied physiology, 2005 - cdnsciencepub.com
L'état actuel des connaissances concernant la prétendue substance hépatique sensibilisant
à l'insuline (HISS) est présenté brièvement. Après un repas, 50-60% des actions de …

Increased incidence of hepatic insulin-sensitizing substance (HISS)-dependent insulin resistance in female rats prenatally exposed to ethanol

P Sadri, DJ Legare, S Takayama… - Canadian journal of …, 2005 - cdnsciencepub.com
L'insuline favorise la libération de la substance sensibilisant à l'insuline hépatique (HISS)
par le foie. Les nerfs parasympathiques hépatiques jouent un rôle permissif dans la …

A proposed new paradigm for insulin resistance

WW Lautt - Metabolic Syndrome and Related Disorders, 2003 - liebertpub.com
The perspective presented here is a working hypothesis suggesting a new paradigm for
insulin resistance where, analogous to the cause of type 1 diabetes being attributed to lack …

Lemmes de multiplicité associés aux groupes triangulaires de Riemann-Schwarz

F Pellarin - arXiv preprint math/0407380, 2004 - arxiv.org
arXiv:math/0407380v1 [math.NT] 22 Jul 2004 Lemmes de multiplicité associés aux groupes
triangulaires de Riemann-Schwarz. Page 1 arXiv:math/0407380v1 [math.NT] 22 Jul 2004 …

New paradigm for insulin resistance: the HISS story

WW Lautt - Atherosclerosis, Hypertension and Diabetes, 2003 - Springer
There is increasing recognition that the insulin resistance state has its major path-ogenic
consequences in the post-meal period when the nutrients from the meal are being …

Into the regulation of glucose homeostasis: from periphery to brain

MP Macedo, PA Lima - 2013 - repositorio.ul.pt
The main goal of this thesis was to have an integrative view both in peripheral glucose
homeostasis and its impact on brain synaptic proteins content. In our first study we …