The management of patients with severe brain injuries and prolonged disorders of
consciousness raises important issues particularly with respect to their therapeutic options …

Traumatic brain injury (TBI) is a looming epidemic, growing most rapidly in the elderly
population. Some of the most devastating sequelae of TBI are related to depressed levels of …

Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Results, Phenotypes of Patients Following LIFU: We highlight three initial results. First, this
report shows that MR-guided LIFU is feasible in (outpatient) chronic DOC patients. Second …

Unresponsive wakefulness syndrome (UWS) patients may retain intact portions of the
thalamocortical system that are spontaneously active and reactive to sensory stimuli but fail …

The promotion of recovery in patients who have entered a disorder of consciousness (DOC;
eg, coma or vegetative states) following severe brain injury remains an enduring medical …

The intralaminar thalamus, in particular the centromedian-parafascicular complex, forms a
strategic node between ascending information from the spinal cord and brainstem and …

Objective To investigate the therapeutic efficacy of repetitive transcranial magnetic
stimulation (rTMS) in patients with disorders of consciousness. Design and Setting We …

Disorders of consciousness are a heterogeneous mixture of different diseases or injuries.
Although some indicators and models have been proposed for prognostication, any single …

The growing understanding of the biology of disorders of consciousness has led to a
renaissance in the development of therapeutic interventions for patients with disorders of …