GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors

A Lippa, MM Poe, JL Smith, X Jin, X Ping… - Pharmacology & …, 2022 - Elsevier
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

[HTML][HTML] Functional dyspepsia: current understanding and future perspective

T Oshima - Digestion, 2024 - karger.com
Background: Functional dyspepsia (FD) is a common disorder characterized by chronic or
recurrent upper abdominal pain or discomfort without any structural abnormalities in the …

British Society of Gastroenterology guidelines on the management of functional dyspepsia

CJ Black, PA Paine, A Agrawal, I Aziz, MP Eugenicos… - Gut, 2022 - gut.bmj.com
Functional dyspepsia (FD) is a common disorder of gut–brain interaction, affecting
approximately 7% of individuals in the community, with most patients managed in primary …

Randomised clinical trial: the effects of pregabalin vs placebo on functional dyspepsia

I Kotikula, N Thinrungroj… - Alimentary …, 2021 - Wiley Online Library
Background Currently, central neuromodulators are among the therapeutic options for the
treatment of functional dyspepsia (FD). Pregabalin, a gabapentinoid, is a neuromodulator …

Autonomic and cytokine mechanisms of acute electroacupuncture in a rodent model of functional dyspepsia

S Zhang, Y Liu, S Li, F Ye, J Yin - Neurogastroenterology & …, 2024 - Wiley Online Library
Background Cytokines have been presumed to play an important role in the
pathophysiology of functional dyspepsia (FD). Electroacupuncture (EA) has been used for …

精神心理因素干预功能性消化不良的研究进展

张颖, 刘海英, 孙琳林, 陈瑞林 - 实用临床医药杂志, 2022 - jcmp.yzu.edu.cn
中国人群功能性消化不良(FD) 发病率呈上升趋势. 目前, FD 发病机制尚不明确,
临床上常用的药物及治疗方法可在一定程度上改善疾病症状, 但却忽视了精神心理因素对疾病 …

The devil is in the detail: a critique of nine editorials published by the International Task Force on Benzodiazepines

J Brandt - BJPsych Advances, 2024 - cambridge.org
Since 2018, the International Task Force on Benzodiazepines (ITFB), a group of academic
psychiatrists and academic psychologists, has advocated that clinical guidelines should …

Efficacy and safety of pinaverium bromide as an add‐on therapy in refractory dyspepsia: A randomized controlled trial

T Kamolsripat, N Thinrungroj, K Pinyopornpanish… - JGH …, 2024 - Wiley Online Library
Abstract Background and Aim Functional dyspepsia (FD) remains a therapeutic challenge,
and the efficacy of antispasmodic agents as adjunctive therapy is not well established. This …

Mechanism of action of cholinergic drugs

KH Reza, PP Das, CM Hossain, MA Shaharyar… - How Synthetic Drugs …, 2023 - Elsevier
The autonomic nervous system (ANS) controls and regulates the whole system of bodily
functions. It works silently, that is, acts unconsciously to maintain the rhythm of a large …

CASE REPORT: EPIGASTRIC PAIN

J Mende, C Elvionita, R Nurkhalika… - Healthy Tadulako …, 2024 - jurnal.fk.untad.ac.id
A male patient (76 years) complained of heartburn since last night, pain scale of 7 to 8 (very
disturbing). Examination of vital signs found increased blood pressure, and the patient's …