Importance of the pig as a human biomedical model
JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface
In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
Molecular structure of the human CFTR ion channel
The cystic fibrosis transmembrane conductance regulator (CFTR) is an ATP-binding
cassette (ABC) transporter that uniquely functions as an ion channel. Here, we present a 3.9 …
cassette (ABC) transporter that uniquely functions as an ion channel. Here, we present a 3.9 …
Cystic fibrosis genetics: from molecular understanding to clinical application
GR Cutting - Nature Reviews Genetics, 2015 - nature.com
The availability of the human genome sequence and tools for interrogating individual
genomes provide an unprecedented opportunity to apply genetics to medicine. Mendelian …
genomes provide an unprecedented opportunity to apply genetics to medicine. Mendelian …
Origins of cystic fibrosis lung disease
DA Stoltz, DK Meyerholz, MJ Welsh - New England Journal of …, 2015 - Mass Medical Soc
Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator
undermine many host defense systems by inhibiting the function of airway-surface liquid …
undermine many host defense systems by inhibiting the function of airway-surface liquid …
The pig as a model for immunology research
R Pabst - Cell and tissue research, 2020 - Springer
The pig is an omnivorous, monogastric species with many advantages to serve as an animal
model for human diseases. There are very high similarities to humans in anatomy and …
model for human diseases. There are very high similarities to humans in anatomy and …
The gastrointestinal mucus system in health and disease
MEV Johansson, H Sjövall, GC Hansson - … reviews Gastroenterology & …, 2013 - nature.com
Mucins—large, highly glycosylated proteins—are important for the luminal protection of the
gastrointestinal tract. Enterocytes have their apical surface covered by transmembrane …
gastrointestinal tract. Enterocytes have their apical surface covered by transmembrane …
[图书][B] Principles of animal nutrition
G Wu - 2017 - taylorfrancis.com
Animals are biological transformers of dietary matter and energy to produce high-quality
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …
Dual SMAD signaling inhibition enables long-term expansion of diverse epithelial basal cells
H Mou, V Vinarsky, PR Tata, K Brazauskas, SH Choi… - Cell stem cell, 2016 - cell.com
Functional modeling of many adult epithelia is limited by the difficulty in maintaining relevant
stem cell populations in culture. Here, we show that dual inhibition of SMAD signaling …
stem cell populations in culture. Here, we show that dual inhibition of SMAD signaling …
An official American Thoracic Society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis
RG Jenkins, BB Moore, RC Chambers… - American journal of …, 2017 - atsjournals.org
Numerous compounds have shown efficacy in limiting development of pulmonary fibrosis
using animal models, yet few of these compounds have replicated these beneficial effects in …
using animal models, yet few of these compounds have replicated these beneficial effects in …