Inflammatory bowel disease: Etiology and pathogenesis - ScienceDirect Skip to main contentSkip
to article Elsevier logo Journals & Books Search RegisterSign in View PDF Download full issue …

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis
(UC) are multifactorial diseases with still unknown aetiology and an increasing prevalence …

Background & Aims: The molecular mechanisms responsible for leukocyte recruitment in
experimental colitis are poorly understood. The aims of this study were to measure …

Adhesion molecule immunoneutralization is envisioned as a promising therapy for
inflammatory bowel disease, but the relative value of selective blockade of different …

Background & Aims: ISIS-2302, an antisense oligonucleotide directed against intercellular
adhesion molecule 1, was effective in steroid refractory Crohn's disease in a pilot trial. The …

Background & Aims: Inflammatory bowel disease is characterized by oxidative and
nitrosative stress, leukocyte infiltration, and up-regulation of intercellular adhesion molecule …

Leukocyte‐endothelial cell interactions are mediated by various cell adhesion molecules.
These interactions are important for leukocyte extravasation and trafficking in all domestic …

The effect of ischemia produced by bilateral occlusion of the common carotid arteries (30
min) followed by 4 hours of reperfusion on total and inducible nitric oxide synthase (NOS) …

Increased expression of intercellular adhesion molecule‐1 (ICAM‐1) in the colon of
inflammatory bowel disease (IBD) has been reported. We evaluated the effects of …

ICAM‐1 (CD54), the ligand for LFA‐1 and Mac‐1, is up‐regulated during inflammatory
reaction on the activated vascular endothelium. To determine its role in intestinal …