Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with a 5-year
survival rate of< 10%. The tumour microenvironment (TME) of PDAC is characterized by …

Abstract The PI3K/AKT/mTOR pathway is frequently activated in various human cancers and
has been considered a promising therapeutic target. Many of the positive regulators of the …

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for
prevention and treatment are urgently needed. We previously reported that histone H4 …

Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation
to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal …

Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells.
Here, we show that oncogenic KRAS (KRAS G12D) also regulates tumor cell signaling via …

Summary The phosphoinositide 3-kinase (PI3K) pathway regulates multiple steps in glucose
metabolism and also cytoskeletal functions, such as cell movement and attachment. Here …

Abstract The Rho GTPases RhoA, Rac1, and Cdc42 are important regulators of cytoskeletal
dynamics. Although many in vitro and in vivo data indicate tumor-promoting effects of …

With 5-year survival rates remaining constant at 6% and rising incidences associated with
an epidemic in obesity and metabolic syndrome, pancreatic ductal adenocarcinoma (PDAC) …

Background Cancer impacts millions of lives globally each year, with approximately 10
million cancer-related deaths recorded worldwide in 2020. Mounting research has …

Rho family GTPases are critical regulators of cellular functions that play important roles in
cancer progression. Aberrant activity of Rho small G-proteins, particularly Rac1 and their …