In this critical review, the progress in catalytic asymmetric synthesis of β-amino acids is
discussed, covering the literature since 2002. The review treats transition metal catalysis …

The prevalence of nitrogen containing heterocycles in natural products and pharmaceuticals
is a doubtless fact. In this review, recent applications of a stereoselective aza-Michael …

The remarkable complexity of globular protein structures was first revealed about half a
century ago, when the crystal structure of myoglobin was determined at 2.4 Å. 1 In the …

The development of organocatalysts has greatly changed the art of organic transformation in
the chemical synthesis community for the past decades. Nature's work underpins the …

Cinchona alkaloids catalyze the enantioselective Mannich reaction of β-keto esters with acyl
aryl imines. The reaction requires 10 mol% of cinchonine or cinchonidine. The reaction …

A novel asymmetric Friedel− Crafts alkylation of indoles with nitroalkenes catalyzed by Zn
(II)− bisoxazoline complexes has been developed. The nitroalkylated indoles are …

β-Amino acids are important synthetic targets due to their presence in a wide variety of
natural products, pharmaceutical agents, and mimics of protein structural motifs. While β …

The bifunctional thiourea–tertiary amine derivatives of simple chiral diamines serve as
highly enantioselective catalysts for the Michael addition of α-substituted cyanoacetates to …

The combined use of chiral Pd complex 2 and amine salt enabled completely regulated
release of free nucleophilic amine. Under these conditions, an efficient catalytic asymmetric …

A highly enantioselective Mannich reaction between malonate esters and N-Boc and N-Cbz
aldimines, catalysed by a bifunctional cinchonine derivative, has been developed; extension …