Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …

NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and
GluN3 subunits. Two different GluN2 subunits have been identified in most NMDA receptor …

N-methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels
('ionotropic'receptors) activated by the major excitatory neurotransmitter, l-glutamate. While …

The subunit composition of N-methyl D-aspartate receptors (NMDARs) is tightly regulated
during cortical development. NMDARs are initially dominated by GluN2B (NR2B), whereas …

NMDA receptors (NMDARs) are a class of ionotropic glutamate receptors (iGluRs) that are
essential for neuronal development, synaptic plasticity, learning and cell survival. Several …

NMDA receptors are part of the ionotropic glutamate receptor family, and are crucial for
neurotransmission and memory. At the cellular level, the effects of activating these receptors …

TDP-43 proteinopathy is linked to neurodegenerative diseases that feature synaptic loss in
the cortex and hippocampus, although it remains unclear how TDP-43 regulates mature …

Acute organophosphorus compound (OP) poisoning induces symptoms of the cholinergic
crises with the occurrence of severe epileptic seizures. Seizures are induced by …

The NMDA subtype of ionotropic glutamate receptor is a sophisticated integrator and
transducer of information. NMDAR-mediated signals control diverse processes across the …