Extracellular acidification is a well-known driver of tumorigenesis that has been extensively
studied. In contrast, the role of endosomal pH is novel and relatively unexplored. There is …

Simple Summary Ischemic stroke is caused by the blockade of a blood vessel in the brain.
Consequently, the brain region supplied by the blocked vessel suffers brain damage and …

Lysosomes require an acidic lumen between pH 4.5 and 5.0 for effective digestion of
macromolecules. This pH optimum is maintained by proton influx produced by the V-ATPase …

Intracellular organelles change their size during trafficking and maturation. This requires the
transport of ions and water across their membranes. Macropinocytosis, a ubiquitous form of …

Background: Ischemia–reperfusion injury (IRI) is one of the major risk factors implicated in
morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the …

It is still an urgent but challenging task to rational design metal organic frameworks (MOFs)-
derived architectures with decent oxygen bifunctionality and durability on substrates for the …

The sense of taste is an important sentinel governing what should or should not be ingested
by an animal, with high pH sensation playing a critical role in food selection. Here we …

Blood-CNS barrier disruption is a hallmark of numerous neurological disorders, yet whether
barrier breakdown is sufficient to trigger neurodegenerative disease remains unresolved …

Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is
fundamental to developmental biology, organ physiology, and immunology. Macrophages …

Tissue acidification is associated with a variety of disease states, and acid-sensing ion
channels (ASICs) that can sense changes in pH have gained traction as possible …