Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …

Human pancreatic β cells have exceptionally high zinc content. In β cells the highest zinc
concentration is in insulin secretory granules, from which it is cosecreted with the hormone …

With rapidly increasing prevalence, diabetes has become one of the major causes of
mortality worldwide. According to the latest studies, genetic information makes substantial …

Islet autoantigens associated with autoimmune type 1 diabetes (T1D) are expressed in
pancreatic β cells, although many show wider patterns of expression in the neuroendocrine …

Zinc is a crucial trace element in the human body, playing a role in various physiological
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …

Zinc transporters (ZnT) form an important class of zinc efflux proteins in mammals. Nine ZnT
transporters, designated ZnT1–ZnT8 and ZnT10, have been identified to date. Recent …

The solute carriers families 30 (SLC30; ZnT), 39 (SLC39; ZIP), and 31 (SLC31; CTR) are
involved in the essential maintenance of cellular zinc (Zn 2+) and copper (Cu 2+) …

Zinc is an essential nutrient with tremendous importance for human health, and zinc
deficiency is a severe risk factor for increased mortality and morbidity. As abnormal zinc …

Objective The SLC30A8 gene encodes the islet-specific transporter ZnT-8, which is
hypothesized to provide zinc for insulin-crystal formation. A polymorphic variant in SLC30A8 …