Paediatric ependymomas are rare, malignant tumours arising throughout the central
nervous system, but most frequently (in children) the posterior fossa. The standard of care for …

Abstract Purpose of Review This review discusses the evidence base behind current and
emerging strategies of management of intracranial and spinal ependymomas in children …

Background The goal of this study was to evaluate outcomes in children with relapsed,
molecularly characterized intracranial ependymoma treated with or without craniospinal …

Background Survival in recurrent ependymomas in children and adolescents mainly
depends on the extent of resection. Studies on repeated radiotherapy and chemotherapy at …

Results: NP-Pt at concentrations of 0.14 µM/ml, 0.29 µM/ml and 0.65 µM/ml had a harmful
influence on viability of U87 glioblastoma multiforme (GBM) cells, but also showed genotoxic …

Background Preclinical studies have suggested that mTOR pathway signaling may be a
potential therapeutic target for childhood ependymoma. Methods A phase II clinical trial …

Ependymomas are neuroepithelial tumors that arise from the ependymal layer bordering the
cerebral ventricles and spinal canal. Intracranial ependymoma represents a major …

During the past three decades there has been a growing appreciation of the late side effects
that therapeutic interventions inflict on childhood cancer survivors. While brain radiotherapy …

Objective/Background: We report efficacy and toxicity outcomes with stereotactic
radiosurgery (SRS) for intracranial and spinal ependymoma. Methods: We analyzed adult …

Aim: This retrospective analysis evaluates feasibility of wide-field re-irradiation using pulsed
reduced dose rate (PRDR) technique in patients with recurrent ependymoma. PRDR …