Herein, we report the synthesis of a series of new quinazoline sulfonamide conjugates 2–16
and their evaluation as potential anticancer agents via dual targeting of EGFR T790M and …

Sixteen new thalidomide analogs were synthesized. The new candidates showed potent in
vitro antiproliferative activities against three human cancer cell lines, namely hepatocellular …

Abstract Seventeen new pyrazolo [3, 4-d] pyrimidine derivatives have been designed,
created and tested as dual VEGFR-2 and EGFR inhibitors for their anticancer special effects …

Novel azobenzene scaffold-joined heterocyclic isoxazole, pyrazole, triazole, and/or triazine
moieties have been developed and synthesized utilizing microwave and traditional …

Herein, we report the synthesis of a series of new fourteen iodoquinazoline derivatives 7a-c
to 13a-e and their evaluation as potential anticancer agents via dual targeting of EGFR …

Alzheimer's disease (AD) is treated by targeting cholinesterase enzymes like
acetylcholinesterase and butyrylcholinesterase, and these enzymes' inhibitors serve as …

Novel phthalazine derivatives were designed, synthesized and evaluated against Hep G2
and MCF-7 as VEGFR-2 inhibitors. In particular, compounds 2g and 4a were found to be the …

It is evident that cancer is a serious disease with a growing incidence and high mortality rate.
Based on the CRBN binding properties of glutarimide moiety of thalidomide molecule, and …

Structural-based drug design and solvent-free synthesis were combined to obtain three
novel series of 5-arylethylidene-aminopyrimidine-2, 4-diones (4, 5a–c, 6a, b), 5 …

Fifteen new 1-alkyl-6-iodoquinazoline derivatives 5a–d to 9a–e were designed and
synthesized and their anticancer activities were evaluated against HepG2, MCF-7, HCT116 …