New quinazoline sulfonamide derivatives as potential anticancer agents: Identifying a promising hit with dual EGFR/VEGFR-2 inhibitory and radiosensitizing activity
Herein, we report the synthesis of a series of new quinazoline sulfonamide conjugates 2–16
and their evaluation as potential anticancer agents via dual targeting of EGFR T790M and …
and their evaluation as potential anticancer agents via dual targeting of EGFR T790M and …
[HTML][HTML] Design, synthesis, and biological evaluation of new potential unusual modified anticancer immunomodulators for possible non-teratogenic quinazoline-based …
RR Mabrouk, AE Abdallah, HA Mahdy… - International Journal of …, 2023 - mdpi.com
Sixteen new thalidomide analogs were synthesized. The new candidates showed potent in
vitro antiproliferative activities against three human cancer cell lines, namely hepatocellular …
vitro antiproliferative activities against three human cancer cell lines, namely hepatocellular …
Pyrazolo [3, 4-d] pyrimidine derivatives as EGFRT790M and VEGFR-2 dual TK inhibitors: Design, synthesis, molecular docking, ADMET profile and anticancer …
Abstract Seventeen new pyrazolo [3, 4-d] pyrimidine derivatives have been designed,
created and tested as dual VEGFR-2 and EGFR inhibitors for their anticancer special effects …
created and tested as dual VEGFR-2 and EGFR inhibitors for their anticancer special effects …
[HTML][HTML] Five and six membered heterocyclic rings endowed with azobenzene as dual EGFR T790M and VEGFR-2 inhibitors: design, synthesis, in silico ADMET …
KE Anwer, SSA El-Hddad, NEA Abd El-Sattar… - RSC …, 2023 - pubs.rsc.org
Novel azobenzene scaffold-joined heterocyclic isoxazole, pyrazole, triazole, and/or triazine
moieties have been developed and synthesized utilizing microwave and traditional …
moieties have been developed and synthesized utilizing microwave and traditional …
Iodoquinazoline-derived VEGFR-2 and EGFRT790M dual inhibitors: Design, synthesis, molecular docking and anticancer evaluations
AA Mohamed, SSA El-Hddad, AKB Aljohani… - Bioorganic …, 2024 - Elsevier
Herein, we report the synthesis of a series of new fourteen iodoquinazoline derivatives 7a-c
to 13a-e and their evaluation as potential anticancer agents via dual targeting of EGFR …
to 13a-e and their evaluation as potential anticancer agents via dual targeting of EGFR …
[HTML][HTML] Synthesis, in vitro analysis and molecular docking study of novel benzoxazole-based oxazole derivatives for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is treated by targeting cholinesterase enzymes like
acetylcholinesterase and butyrylcholinesterase, and these enzymes' inhibitors serve as …
acetylcholinesterase and butyrylcholinesterase, and these enzymes' inhibitors serve as …
[HTML][HTML] Exploration of the VEGFR-2 inhibition activity of phthalazine derivatives: design, synthesis, cytotoxicity, ADMET, molecular docking and dynamic simulation
HH Bayoumi, MK Ibrahim, MA Dahab, F Khedr… - RSC …, 2024 - pubs.rsc.org
Novel phthalazine derivatives were designed, synthesized and evaluated against Hep G2
and MCF-7 as VEGFR-2 inhibitors. In particular, compounds 2g and 4a were found to be the …
and MCF-7 as VEGFR-2 inhibitors. In particular, compounds 2g and 4a were found to be the …
Design, synthesis and biological evaluation of newly triazolo-quinoxaline based potential immunomodulatory anticancer molecules
MMS Al Ward, AE Abdallah, MF Zayed… - Journal of Molecular …, 2024 - Elsevier
It is evident that cancer is a serious disease with a growing incidence and high mortality rate.
Based on the CRBN binding properties of glutarimide moiety of thalidomide molecule, and …
Based on the CRBN binding properties of glutarimide moiety of thalidomide molecule, and …
[HTML][HTML] Novel Aminopyrimidine-2, 4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity …
S El-Kalyoubi, SA El-Sebaey, SM Elfeky… - Pharmaceuticals, 2023 - mdpi.com
Structural-based drug design and solvent-free synthesis were combined to obtain three
novel series of 5-arylethylidene-aminopyrimidine-2, 4-diones (4, 5a–c, 6a, b), 5 …
novel series of 5-arylethylidene-aminopyrimidine-2, 4-diones (4, 5a–c, 6a, b), 5 …
[HTML][HTML] Design, synthesis, docking, ADMET and anticancer evaluations of N-alkyl substituted iodoquinazoline derivatives as dual VEGFR-2 and EGFR inhibitors
Fifteen new 1-alkyl-6-iodoquinazoline derivatives 5a–d to 9a–e were designed and
synthesized and their anticancer activities were evaluated against HepG2, MCF-7, HCT116 …
synthesized and their anticancer activities were evaluated against HepG2, MCF-7, HCT116 …