Membrane transporters can be major determinants of the pharmacokinetic, safety and
efficacy profiles of drugs. This presents several key questions for drug development …

One approach to speed up drug discovery is to examine new uses for existing approved
drugs, so-called 'drug repositioning'or 'drug repurposing', which has become increasingly …

Peptide transport is currently a prominent topic in membrane research. The transport
proteins involved are under intense investigation because of their physiological importance …

A major hurdle impeding the successful clinical development of drug candidates can be
poor intestinal permeability. Low intestinal permeability may be enhanced by a prodrug …

The Pharmacogenomics Journal (2006) 6, 360–374. doi: 10.1038/sj. tpj. 6500384;
published online 21 March 2006 β-hydroxy-β-methylglutaryl Coenzyme A (HMG-CoA) …

The hepatic bile acid uptake transporter sodium taurocholate cotransporting polypeptide
(NTCP) is less well characterized than its ileal paralog, the apical sodium dependent bile …

The pharmaceutical relevance of proton-coupled peptide transporters is currently under
intense investigation in many laboratories. Studies have shown that these membrane …

The ability to identify ligands for drug transporters is an important step in drug discovery and
development. It can both improve accurate profiling of lead pharmacokinetic properties and …

This book provides a comprehensive introduction to advanced drug delivery and targeting,
covering their principles, current applications, and potential future developments. This …

Purpose The goals of the present study were to apply a generalized regression model and
support vector machine (SVM) models with Shape Signatures descriptors, to the domain of …