The structure and integrity of telomeres are essential for genome stability. Telomere
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …

Telomerase is a special reverse transcriptase ribonucleoprotein dedicated to the synthesis
of telomere repeats that protect chromosome ends. Among reverse transcriptases …

A common hallmark of human cancers is the overexpression of telomerase, a
ribonucleoprotein complex that is responsible for maintaining the length and integrity of …

Abstract The Nobel Prize in Physiology or Medicine was recently awarded to Elizabeth
Blackburn, Carol Greider and Jack Szostak for their pioneering studies on chromosome …

Telomerase is a reverse transcriptase specialized in the addition of telomeric DNA repeats
onto the ends of chromosomes. Telomere extension offsets the loss of telomeric repeats …

BIBR1532 is a highly specific telomerase inhibitor, although the molecular basis for
inhibition is unknown. Here we present the crystal structure of BIBR1532 bound to Tribolium …

Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the
shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA …

Since 1998, there have been great advances in our understanding of the pathogenesis of
dyskeratosis congenita (DC), a rare inherited bone marrow failure and cancer predisposition …

Human telomerase has two core components, the RNA molecule (TERC) that provides the
template for telomere repeat elongation and a reverse transcriptase (TERT) that is …