Deuterium in drug discovery: progress, opportunities and challenges
RMC Di Martino, BD Maxwell, T Pirali - Nature Reviews Drug Discovery, 2023 - nature.com
Substitution of a hydrogen atom with its heavy isotope deuterium entails the addition of one
neutron to a molecule. Despite being a subtle change, this structural modification, known as …
neutron to a molecule. Despite being a subtle change, this structural modification, known as …
Pathophysiology, prognosis and treatment of tardive dyskinesia
H Takeuchi, Y Mori, Y Tsutsumi - Therapeutic advances in …, 2022 - journals.sagepub.com
Tardive dyskinesia (TD), a movement disorder associated with antipsychotics, most
frequently affects the lower face and jaw muscles, but can also affect walking, breathing and …
frequently affects the lower face and jaw muscles, but can also affect walking, breathing and …
Assessment of the impact of tardive dyskinesia in clinical practice: consensus panel recommendations
R Jackson, MN Brams, L Citrome… - Neuropsychiatric …, 2021 - Taylor & Francis
Purpose Tardive dyskinesia (TD) is a hyperkinetic movement disorder in which patients
experience abnormal involuntary movements that can have profound negative impacts on …
experience abnormal involuntary movements that can have profound negative impacts on …
[HTML][HTML] Treatment of dystonia: medications, neurotoxins, neuromodulation, and rehabilitation
IO Bledsoe, AC Viser, M San Luciano - Neurotherapeutics, 2020 - Elsevier
Dystonia is a complex disorder with numerous presentations occurring in isolation or in
combination with other neurologic symptoms. Its treatment has been significantly improved …
combination with other neurologic symptoms. Its treatment has been significantly improved …
Treatment of tardive dyskinesia
HH Bashir, J Jankovic - Neurologic Clinics, 2020 - neurologic.theclinics.com
The term, tardive dyskinesia (TD), originally was coined by Faurbye and colleagues 1 in
their description of delayed-onset, persistent, rhythmic, stereotyped movements after …
their description of delayed-onset, persistent, rhythmic, stereotyped movements after …
Vesicular monoamine transporter (VMAT) regional expression and roles in pathological conditions
M Alwindi, A Bizanti - Heliyon, 2023 - cell.com
Vesicular monoamine transporters (VMATs) are key regulators of neurotransmitter release
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …
responsible for controlling numerous physiological, cognitive, emotional, and behavioral …
Movement disorders of the mouth: a review of the common phenomenologies
CM Ghadery, LV Kalia, BS Connolly - Journal of Neurology, 2022 - Springer
Movement disorders of the mouth encompass a spectrum of hyperactive movements
involving the muscles of the orofacial complex. They are rare conditions and are described …
involving the muscles of the orofacial complex. They are rare conditions and are described …
Tardive dyskinesia in older persons taking antipsychotics
L Citrome, SH Isaacson, D Larson… - … Disease and Treatment, 2021 - Taylor & Francis
Tardive dyskinesia (TD) is a hyperkinetic movement disorder caused by the use of
dopamine receptor-blocking agents (DRBAs), a category of medications that includes first …
dopamine receptor-blocking agents (DRBAs), a category of medications that includes first …
Efficacy and safety of valbenazine in Japanese patients with tardive dyskinesia: A multicenter, randomized, double‐blind, placebo‐controlled study (J‐KINECT)
J Horiguchi, K Watanabe, K Kondo… - Psychiatry and …, 2022 - Wiley Online Library
Aim Valbenazine is approved in the US for treatment of tardive dyskinesia (TD); however,
efficacy/safety data in Asian populations are lacking. We assessed the efficacy/safety of …
efficacy/safety data in Asian populations are lacking. We assessed the efficacy/safety of …
[HTML][HTML] Management of tardive syndrome: medications and surgical treatments
SA Factor - Neurotherapeutics, 2020 - Elsevier
Tardive syndrome (TS) is an iatrogenic, often persistent movement disorder caused by drugs
that block dopamine receptors. It has a broad phenotype including movement …
that block dopamine receptors. It has a broad phenotype including movement …