Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

Osteoporosis (OP) is a systemic disease characterized by decreased bone mass and
degeneration of bone microstructure. In recent years, more and more researches have …

The upstream role of sensory innervation during bone homeostasis is widely
underestimated in bone repairing strategies. Herein, a neuromodulation approach is …

Abstract Purpose of Review Despite advances in orthopedics, there remains a need for
therapeutics to hasten fracture healing. However, little focus is given to the role the nervous …

Calcitonin gene-related peptide (CGRP) has 37 amino acids. Initially, CGRP had
vasodilatory and nociceptive effects. As research progressed, evidence revealed that the …

Abstract Purpose of Review Fractures are a prominent form of traumatic injury and shall
continue to be for the foreseeable future. While the inflammatory response and the cells of …

Abstract Purpose of Review The traditionally understated role of neural regulation in fracture
healing is gaining prominence, as recent findings underscore the peripheral nervous …

Osteoporosis is a chronic age-related disease. During aging, bone marrow-derived
mesenchymal stem cells (BMSCs) display increased adipogenic, along with decreased …

Calcitonin gene‐related peptide (CGRP) is a neuropeptide produced by sensory nerves and
functions as a pain sensor. It acts by binding to the calcitonin‐like receptor (CLR, protein; …