Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

Connexins are chordate gap junction channel proteins that, by enabling direct
communication between the cytosols of adjacent cells, create a unique cell signalling …

Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

Potassium (K+) channels have been evolutionarily tuned for activation by diverse biological
stimuli, and pharmacological activation is thought to target these specific gating …

K+ channels with two-pore domain (K2p) form a large family of hyperpolarizing channels.
They produce background currents that oppose membrane depolarization and cell …

Over the last decade, we have seen an enormous increase in the number of experimental
studies on two-pore-domain potassium channels (K 2P-channels). The collection of reviews …

K+ channels fulfill roles spanning from the control of excitability to the regulation of
transepithelial transport. Here we review two groups of K+ channels, pH-regulated K2P …

Two-pore domain potassium (K2P) channels stabilize the resting membrane potential of
both excitable and nonexcitable cells and, as such, are important regulators of cell activity …

Ongoing/spontaneous pain behavior is associated with ongoing/spontaneous firing (SF) in
adult DRG C-fiber nociceptors. Causes of this SF are not understood. We show here that …

Store-operated calcium entry is an almost ubiquitous signaling pathway in eukaryotic cells.
The plasma membrane store-operated channels are comprised of subunits of the recently …