Neural membranes contain several classes of glycerophospholipids which turnover at
different rates with respect to their structure and localization in different cells and …

Abstract Phospholipase A2 (PLA2) enzymes are critical regulators of prostaglandin and
leukotriene synthesis and can directly modify the composition of cellular membranes,. PLA2 …

Neural membrane phospholipids are hydrolyzed by a group of enzymes known as
phospholipases. This process results in the generation of second messengers such as …

Secretory phospholipases A 2 (sPLA 2 s) represent a rapidly expanding family of structurally
related enzymes found in mammals as well as in insect and snake venoms. In this report, a …

Background: Magnetic resonance spectroscopy studies have suggested above-normal
turnover of membrane phospholipids in brains of patients with schizophrenia. One possible …

Many recent studies have emphasized the deleterious role of inflammation in CNS injury.
Increases in free fatty acids, eicosanoids, and products of lipid peroxidation are known to …

The phospholipases A2 (PLA2) belong to a large family of enzymes involved in the
generation of several second messengers that play an important role in signal transduction …

Surfactin inhibits platelet and spleen cytosolic 100 kDa phospholipase A2 (PLA2). In
contrast, this same compound enhances rat platelet group II PLA2 activity by∼ 2-fold and …

We recently reported that the activity of a calcium-independent subtype of phospholipase A2
is increased in blood of patients with schizophrenia. The present investigation examined …

Damage to brain membrane phospholipids may play an important role in the pathogenesis
of Alzheimer's disease (AD); however, the critical metabolic processes responsible for the …