Molecular docking has become an important component of the drug discovery process.
Since first being developed in the 1980s, advancements in the power of computer hardware …

Pyrazole and its derivatives are considered a pharmacologically important active scaffold
that possesses almost all types of pharmacological activities. The presence of this nucleus in …

The necessity for the discovery of innovative antimicrobials to treat life-threatening diseases
has increased as multidrug-resistant bacteria has spread. Due to antibiotics' availability over …

One-third of the world's population infected tuberculosis (TB), and more than 1 million
deaths annually. The co-infection between the mainly pathogen Mycobacterium tuberculosis …

Introduction In fragment-based drug design, fragment linking is a popular strategy where two
fragments binding to different sub-pockets of a target are linked together. This attractive …

Infectious diseases remain a significant threat to human health, contributing to more than 17
million deaths, annually. With the worsening trends of drug resistance, there is a need for …

Multi-drug-resistant tuberculosis (TB) is a major public health problem, concerning about
half a million cases each year. Patients hardly adhere to the current strict treatment …

The quest for new antifungal and antitubercular drugs is a need of the hour because of
morbid co-pathogenesis and an increase in immunocompromised patients. One of the ways …

Cancer is a rapidly growing disease in modern society. Chemotherapy is the first choice for
cancer treatment. Design and development of new chemotherapeutic drugs by targeting …

The 2019 emergence of, SARS-CoV-2 has tragically taken an immense toll on human life
and far reaching impacts on society. There is a need to identify effective antivirals with …