Highlights•Breakthrough in automatic neuron reconstruction from VEM data will enable the
reconstruction of much larger data sets in the future.•Volume electron microscopy imaging …

The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

As the old adage goes: practice makes perfect. Yet, the neural mechanisms by which rote
repetition transforms a halting behavior into a fluid, effortless, and “automatic” action are not …

INTRODUCTION The brain of mammals consists of an enormously dense network of
neuronal wires: the axons and dendrites of nerve cells. Their packing density is so high that …

To investigate circuit mechanisms underlying locomotor behavior, we used serial-section
electron microscopy (EM) to acquire a synapse-resolution dataset containing the ventral …

Reconstruction of neural circuits from volume electron microscopy data requires the tracing
of cells in their entirety, including all their neurites. Automated approaches have been …

Electron microscopy (EM) is widely used for studying cellular structure and network
connectivity in the brain. We have built a parallel imaging pipeline using transmission …

While motor cortical circuits contain information related to specific movement parameters,
long-range inputs also have a critical role in action execution,. Thalamic projections can …

Large-scale connectomic reconstruction of neural circuitry at single-synapse resolution is an
attractive target for improving understanding of the nervous system in health and disease …

We present an auxiliary learning task for the problem of neuron segmentation in electron
microscopy volumes. The auxiliary task consists of the prediction of local shape descriptors …