The blood–brain barrier is playing a critical role in controlling the influx and efflux of
biological substances essential for the brain's metabolic activity as well as neuronal function …

Multiple Sclerosis (MS) is considered the most frequent inflammatory demyelinating disease
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS), which gives rise to focal lesions in the gray and white matter and to …

The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells
through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular …

Immune responses depend on the ability of leukocytes to move from the circulation into
tissue. This is enabled by mechanisms that guide leukocytes to the right exit sites and allow …

Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into the CNS, yet we
lack a comprehensive understanding of the signaling pathways that regulate this process …

Barriers between circulation and the central nervous system (CNS) play a key role in the
development and modulation of CNS immune responses. Structural variations in the …

Epigenetic modifications on DNA and histones regulate gene expression by modulating
chromatin accessibility to transcription machinery. Here we identify methionine as a key …

The Blood Brain Barrier (BBB) is a specialized vascular structure tightly regulating central
nervous system (CNS) homeostasis. Endothelial cells are the central component of the BBB …

Abstract Interleukin-17-expressing CD4+ T helper 17 (Th17) cells are considered as critical
regulators of multiple sclerosis disease activity. However, depending on the species and pro …