The nuclear pore complex (NPC) is the sole gateway between the nucleus and the
cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous …

The study of the Nuclear Pore Complex (NPC), the proteins that compose it (nucleoporins),
and the nucleocytoplasmic transport that it controls have revealed an unexpected layer to …

Single-molecule localization microscopy is used to construct super-resolution images, but
generally requires prior intense laser irradiation and in some cases additives, such as thiols …

Insulin and insulin-like growth factor 1 (IGF-1) receptors share many downstream signaling
pathways but have unique biological effects. To define the molecular signals contributing to …

Copy number variants (CNVs) of the Williams–Beuren syndrome (WBS) 7q11. 23 region are
responsible for neurodevelopmental disorders with multi-system involvement and variable …

Many extracellular signal–regulated kinase (ERK) mitogen-activated protein (MAP) kinase
substrates have been identified, but the diversity of ERK-mediated processes suggests the …

Assembly of the nuclear pore, gateway to the genome, from its component subunits is a
complex process. In higher eukaryotes, nuclear pore assembly begins with the binding of …

The translocation of large macromolecules through the nuclear pore complex (NPC) of
eukaryotic cells is hindered by the phenylalanine-glycine (FG) nucleoporin (Nup) barrier …

Nuclear pore complexes (NPCs) control the movement of molecules across the nuclear
envelope (NE). We investigated the molecular interactions that exist at the interface between …

The nuclear pore complex (NPC) is a large protein assembly that mediates molecular
trafficking between the cytoplasm and the nucleus. NPCs assemble twice during the cell …