Inflammatory gastrointestinal (GI) diseases and malignancies are associated with growing
morbidity and cancer-related mortality worldwide. GI tumor and inflammatory cells contain …

Sphingosine kinases (isoforms SK1 and SK2) catalyse the formation of a bioactive lipid,
sphingosine 1-phosphate (S1P). S1P is a well-established ligand of a family of five S1P …

Arctigenin (ATG) is a major component of Fructus Arctii, a traditional herbal remedy that
reduced proteinuria in diabetic patients. However, whether ATG specifically provides …

Aberrant activation of signal transduction pathways can transform a normal cell to a
malignant one and can impart survival properties that render cancer cells resistant to …

FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple
sclerosis that sequesters T-cells to lymph nodes through functional antagonism of …

Propagation of transient signals requires coordinated suppression of antagonistic
phosphatase activity. Protein phosphatase 2A (PP2A) is a broad specificity serine/threonine …

Abstract Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric enzyme that
catalyzes the selective removal of phosphate groups from protein serine and threonine …

Pancreatic cancer is a deadly disease that is usually diagnosed in the advanced stages
when few effective therapies are available. Given the aggressive clinical course of this …

Simple Summary Sphingolipids, which are important cell membrane components, have
critical roles in regulating cancer cell signaling to control pro-tumoral or antitumoral …

Venetoclax combination therapies are becoming the standard of care in acute myeloid
leukemia (AML). However, the therapeutic benefit of these drugs in older/unfit patients is …