The use of many halogenated alkanes such as carbon tetrachloride (CCl4), chloroform
(CHCl3) or iodoform (CHI3), has been banned or severely restricted because of their distinct …

Because of its unique function and anatomical location, the liver is exposed to a multitude of
toxins and xenobiotics, including medications and alcohol, as well as to infection by …

AIM: To investigate the relationship between the gutliver axis and nonalcoholic fatty liver
disease (NAFLD), we performed a meta-analysis to evaluate the effects of probiotic therapy …

The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of
clinical drug development and the most frequent cause of post-marketing warnings and …

For a long time necrosis was considered as an alternative to programmed cell death,
apoptosis. Indeed, necrosis has distinct morphological features and it is accompanied by …

The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …

Liver fibrosis can be considered as a dynamic and highly integrated cellular response to
chronic liver injury [1]. Whatever the etiology, the evolution of chronic liver disease (CLD) is …

Necrosis has long been described as a consequence of physico-chemical stress and thus
accidental and uncontrolled. Recently, it is becoming clear that necrotic cell death is as well …

Ethnopharmacological relevance Liver disease is a major cause of illness and death
worldwide which accounts for approximately 2 million deaths per year worldwide, 1 million …

Oxidative stress is implicated in the pathogenesis of non-alcoholic fatty liver disease
(NAFLD). In the present study, hepatic and plasma oxidative stress-related parameters were …