The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

Lithium is the first line therapy of bipolar mood disorder. Lithium-induced nephrogenic
diabetes insipidus (Li-NDI) and lithium nephropathy (Li-NP, ie, renal insufficiency) are …

Trace amounts of lithium are essential for our physical and mental health, and administration
of lithium has improved the quality of life of millions of patients with bipolar disorder for> 60 …

Hyponatremia is frequently encountered in clinical practice and usually induced by renal
water retention. Many medications are considered to be among the various causes of …

Activation of autophagy in Schwann cells (SCs) has emerged as a powerful trigger for
peripheral nerve injury (PNI) repair. Lithium ion (Li+) is a classical autophagy activator that …

Nephrogenic diabetes insipidus (NDI) is characterized by the inability to concentrate urine
that results in polyuria and polydipsia, despite having normal or elevated plasma …

Organoid technology is rapidly gaining ground for studies on organ (patho) physiology.
Tubuloids are long-term expanding organoids grown from adult kidney tissue or urine. The …

Previously, we localized ADP-activated P2Y 12 receptor (R) in rodent kidney and showed
that its blockade by clopidogrel bisulfate (CLPD) attenuates lithium (Li)-induced …

Polycystic kidney diseases (PKD) are a group of inherited nephropathies marked with the
formation of fluid-filled cysts along the nephron. This renal disorder affects millions of people …

An ideal inducible system should be cell specific and have absolutely no background
recombination without induction (ie, no leakiness), a high recombination rate after induction …