Dynamics and mechanisms of CNS myelination

KK Bercury, WB Macklin - Developmental cell, 2015 - cell.com
Vertebrate myelination is an evolutionary advancement essential for motor, sensory, and
higher-order cognitive function. CNS myelin, a multilamellar differentiation of the …

[HTML][HTML] Glial-neuron crosstalk in health and disease: A focus on metabolism, obesity, and cognitive impairment

RE Henn, MH Noureldein, SE Elzinga, B Kim… - Neurobiology of …, 2022 - Elsevier
Dementia is a complex set of disorders affecting normal cognitive function. Recently, several
clinical studies have shown that diabetes, obesity, and components of the metabolic …

[HTML][HTML] Human iPSC glial mouse chimeras reveal glial contributions to schizophrenia

MS Windrem, M Osipovitch, Z Liu, J Bates… - Cell stem cell, 2017 - cell.com
In this study, we investigated whether intrinsic glial dysfunction contributes to the
pathogenesis of schizophrenia (SCZ). Our approach was to establish humanized glial …

The astrocyte: powerhouse and recycling center

B Weber, LF Barros - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Brain metabolism is characterized by fuel monodependence, high-energy expenditure,
autonomy from the rest of body, local recycling, and marked division of labor between cell …

Remyelination after spinal cord injury: is it a target for repair?

JR Plemel, MB Keough, GJ Duncan, JS Sparling… - Progress in …, 2014 - Elsevier
After spinal cord injury (SCI) there is prolonged and dispersed oligodendrocyte cell death
that is responsible for widespread demyelination. To regenerate this lost myelin, many …

N-Acetylaspartate reductions in brain injury: impact on post-injury neuroenergetics, lipid synthesis, and protein acetylation

JR Moffett, P Arun, PS Ariyannur… - Frontiers in …, 2013 - frontiersin.org
N-Acetylaspartate (NAA) is employed as a non-invasive marker for neuronal health using
proton magnetic resonance spectroscopy (MRS). This utility is afforded by the fact that NAA …

Functional MRS studies of GABA and glutamate/Glx–A systematic review and meta-analysis

D Pasanta, JL He, T Ford, G Oeltzschner… - Neuroscience & …, 2023 - Elsevier
Functional magnetic resonance spectroscopy (fMRS) can be used to investigate
neurometabolic responses to external stimuli in-vivo, but findings are inconsistent. We …

In vivo imaging of neuroinflammation in schizophrenia

O Pasternak, M Kubicki, ME Shenton - Schizophrenia research, 2016 - Elsevier
In recent years evidence has accumulated to suggest that neuroinflammation might be an
early pathology of schizophrenia that later leads to neurodegeneration, yet the exact role in …

Astrocytes as master modulators of neural networks: Synaptic functions and disease‐associated dysfunction of astrocytes

JA Stogsdill, CC Harwell… - Annals of the New York …, 2023 - Wiley Online Library
Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

Demyelination as a rational therapeutic target for ischemic or traumatic brain injury

H Shi, X Hu, RK Leak, Y Shi, C An, J Suenaga… - Experimental …, 2015 - Elsevier
Previous research on stroke and traumatic brain injury (TBI) heavily emphasized
pathological alterations in neuronal cells within gray matter. However, recent studies have …