Objective: To review the literature to examine the use of clozapine levels to (i) guide therapy
and prevent toxicity in clinical care and (ii) determine cause of death in post-mortem …

BACKGROUND: Personal beliefs about medication compliance have been reliably
associated with emotional and behavioral response to mental health problems and health …

Despite its unsurpassed efficacy in treatment-resistant schizophrenia, clozapine remains
underutilized. Trends in the prescription of clozapine in patients with ICD-10 F20. x …

This work describes the development of a simple, sensitive and selective method based on
high-performance liquid chromatography coupled to tandem mass spectrometry (LC–MS …

Background Clozapine, an antipsychotic used in treatment-resistant schizophrenia, causes
slow gastrointestinal transit in 50–80% of patients. Clozapine-induced gastrointestinal …

A high-throughput quantitative analytical method based on Direct Analysis in Real Time
tandem mass spectrometry (DART-MS/MS) has been developed and validated for the …

This study reports on the development of a rapid, selective, and sensitive column-switching
liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to analyze sixteen …

Objective To describe clozapine prescribing in a mental health service in Auckland, New
Zealand and compare it with national and international treatment guidelines. Setting A large …

Background: Why psychiatrists choose a particular dose of antipsychotic for an individual
patient with schizophrenia is unknown. This study aimed to investigate consultant …

Background: Clozapine is the only Food and Drug Administration (FDA) and National
Institute for Care and Excellence (NICE) approved drug for treatment-resistant schizophrenia …