Ivermectin Exerts Anticonvulsant Effects Against Status Epilepticus Induced by Lithium-Pilocarpine in Rats via GABAA Receptor and Neuroinflammation Modulation: Possible …

MA Manavi, S Toutounchian, S Afsahi… - Molecular …, 2024 - Springer
Status epilepticus (SE) is a critical medical emergency marked by persistent or rapidly
repeating seizures, posing a threat to life. Using the lithium-pilocarpine-induced SE model …

Ivermectin protects against experimental autoimmune encephalomyelitis in mice by modulating the Th17/Treg balance involved in the IL-2/STAT5 pathway

Y Xie, C Jin, H Sang, W Liu, J Wang - Inflammation, 2023 - Springer
Multiple sclerosis (MS), a T-cell-mediated autoimmune disease that affects the central
nervous system (CNS), is characterized by white matter demyelination, axon destruction …

Repositioning anthelmintics for the treatment of inflammatory-based pathological conditions

DCN Rodrigues, JCS Porto, IL dos Santos… - …, 2024 - Springer
Acute, uncontrolled and/or long-lasting inflammation causes a breakdown in immunological
tolerance, leading to chronicity and contributing to a series of significant local or systemic …

Ivermectin: recent approaches in the design of novel veterinary and human medicines

MC Velho, DF de Andrade… - Pharmaceutical …, 2022 - Taylor & Francis
Ivermectin (IVM) is a drug widely used in veterinary and human medicine for the
management of parasitic diseases. Its repositioning potential has been recently considered …

[HTML][HTML] Ivermectin contributes to attenuating the severity of acute lung injury in mice

Y Ma, X Xu, H Wu, C Li, P Zhong, Z Liu, C Ma… - Biomedicine & …, 2022 - Elsevier
Ivermectin has been proposed as a potential anti-inflammatory drug in addition to its
antiparasitic activity. Here we investigated the potential role of ivermectin in the …

Possible interaction of opioidergic and nitrergic pathways in the anticonvulsant effect of ivermectin on pentylenetetrazole-induced clonic seizures in mice

S Jourian, M Rahimi, MA Manavi… - Neurochemical …, 2023 - Springer
Ivermectin (IVM) is an antiparasitic drug that primarily works by the activation of GABAA
receptors. The potential pharmacological pathways behind the anti-convulsant effect of IVM …

Anticonvulsant effects of ivermectin on pentylenetetrazole-and maximal electroshock-induced seizures in mice: the role of GABAergic system and KATP channels

MA Manavi, RM Jafari, H Shafaroodi, S Ejtemaei-Mehr… - Heliyon, 2022 - cell.com
Introduction Ivermectin (IVM) is an antiparasitic medicine that exerts its function through
glutamate-gated chloride channels and GABA A receptors predominantly. There is paucity of …

Ivermectin ameliorates bleomycin-induced lung fibrosis in male rats by inhibiting the inflammation and oxidative stress

F Habibi Razi, R Mohammad Jafari… - …, 2024 - Taylor & Francis
Background Idiopathic pulmonary fibrosis (IPF) is a pulmonary fibrotic disease characterized
by a poor prognosis, which its pathogenesis involves the accumulation of abnormal fibrous …

P2X4 receptor modulates gut inflammation and favours microbial homeostasis in colitis

P Zhong, H Wu, Y Ma, X Xu, Y Jiang… - Clinical and …, 2023 - Wiley Online Library
Background Inflammatory bowel disease (IBD) is a non‐specific chronic inflammatory
disease of the intestine. In addition to genetic susceptibility, environmental factors and …

Cannabidiol improves random-pattern skin flap survival in rats: involvement of cannabinoid type-2 receptors

A Aryannejad, F Eslami, M Shayan… - Journal of …, 2023 - thieme-connect.com
Background One of the major complications associated with random-pattern skin flaps is
distal necrosis. Cannabidiol (CBD) has recently gained much attention as a therapeutic anti …