[HTML][HTML] PET agents in dementia: an overview

A van Waarde, S Marcolini, PP De Deyn… - Seminars in nuclear …, 2021 - Elsevier
This article presents an overview of imaging agents for PET that have been applied for
research and diagnostic purposes in patients affected by dementia. Classified by the target …

Synthesis of [11C]BIIB104, an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic-Acid-Positive Allosteric Modulator, and Evaluation of the Bio-Distribution in Non …

S Nag, K Jia, R Arakawa, P Datta, D Scott, C Shaffer… - Molecules, 2024 - mdpi.com
The aim of this study was to measure the brain penetrance and kinetics of BIIB104, a first-in-
class AMPA receptor potentiator developed for cognitive impairment associated with …

[HTML][HTML] Evaluation of thiadiazine-based PET radioligands for imaging the AMPA receptor

J Chen, W Ran, Y Huang, J Wei, J Rong, H Wei… - Biomedicine & …, 2023 - Elsevier
As a subclass of ionotropic glutamate receptors (iGluRs), α-amino-3-hydroxyl-5-methyl-4-
isoxazolepropionic acid (AMPA) receptors have been implicated in various neurological …

Synthesis, crystal structure, Hirshfeld surface and interaction energies analysis of 5-methyl-1, 3-bis (3-nitrobenzyl) pyrimidine-2, 4 (1H, 3H)-dione

KS Etsè, LC Lamela, G Zaragoza… - European Journal of …, 2020 - eurjchem.com
Abstract The title compound 5-methyl-1, 3-bis (3-nitrobenzyl) pyrimidine-2, 4 (1H, 3H)-dione
was obtained by reaction of thymine with 3-nitrobenzylbromide in the presence of cesium …

The Current State and Future Outlook of PET Tracers for AMPA Receptors

L Li, S Wen, J Dai - Neuroscience Bulletin, 2024 - Springer
Accepted: 13 September 2024© Center for Excellence in Brain Science and Intelligence
Technology, Chinese Academy of Sciences 2024 kinetics, pharmacology, localization, and …

Conception de modulateurs allostériques positifs des récepteurs AMPA-Contribution à la synthèse des 1, 4-benzothiazines 1, 1-dioxydes

J Jenniges - 2019 - matheo.uliege.be
La synthèse d'un dérivé benzothiazine 1, 1-dioxyde, à savoir le 4-(2-fluoroéthyle)-7-phénoxy-
3, 4-dihydro-2H-1, 4-benzothiazine 1, 1-dioxyde (VI), a été étudiée sur base de cinq …