The intricate link between membrane lipid structure and composition and membrane structural properties in bacterial membranes

TH Lee, P Charchar, F Separovic, GE Reid… - Chemical …, 2024 - pubs.rsc.org
It is now evident that the cell manipulates lipid composition to regulate different processes
such as membrane protein insertion, assembly and function. Moreover, changes in …

Designing a green-emitting viscosity-sensitive 4, 4-difluoro-4-bora-3a, 4a-diaza-s-indacene (BODIPY) probe for plasma membrane viscosity imaging

A Polita, M Stancikaitė, R Žvirblis, K Maleckaitė… - RSC …, 2023 - pubs.rsc.org
Viscosity is a key characteristic of lipid membranes–it governs the passive diffusion of
solutes and affects the lipid raft formation and membrane fluidity. Precise determination of …

Ratiometric fluorescence nanoscopy and lifetime imaging of novel Nile Red analogs for analysis of membrane packing in living cells

L Lauritsen, M Szomek, M Hornum, P Reinholdt… - Scientific Reports, 2024 - nature.com
Subcellular membranes have complex lipid and protein compositions, which give rise to
organelle-specific membrane packing, fluidity, and permeability. Due to its exquisite solvent …

Amplifying the Negative Solvatochromism of Pyridinium Phenolates via Fluorene Conjugation

I Zharinova, N Saker Neto, WWH Wong - Chemistry of Materials, 2023 - ACS Publications
New chromophores carrying a donor phenolate group and an acceptor pyridyl moiety
separated by a fluorene spacer are reported. A progressive elongation of the systems was …

Quantifying Fluorescence Lifetime Responsiveness of Environment-Sensitive Probes for Membrane Fluidity Measurements

F Ragaller, E Sjule, YB Urem, J Schlegel… - The Journal of …, 2024 - ACS Publications
The structural diversity of different lipid species within the membrane defines its biophysical
properties such as membrane fluidity, phase transition, curvature, charge distribution, and …

Julolidine-based small molecular probes for fluorescence imaging of RNA in live cells

IC Mondal, P Rawat, M Galkin, S Deka… - Organic & …, 2023 - pubs.rsc.org
Intracellular RNA imaging with organic small molecular probes has been an intense topic,
although the number of such reported dyes, particularly dyes with high quantum yields and …

Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties

F Ragaller, L Andronico, J Sykora, W Kulig… - Open …, 2022 - royalsocietypublishing.org
The plasma membrane, as a highly complex cell organelle, serves as a crucial platform for a
multitude of cellular processes. Its collective biophysical properties are largely determined …

Synthesis and photophysical properties of a new push–pull pyrene dye with green-to-far-red emission and its application to human cellular and skin tissue imaging

K Inoue, R Kawakami, M Murakami… - Journal of Materials …, 2022 - pubs.rsc.org
Herein, we discuss a new pyrene-based push–pull dye (PC) and our investigation of its
photophysical properties and applicability to biological studies. The newly synthesized dye …

Differences in interaction lead to the formation of different types of insulin amyloid

W Mori, R Kawakami, Y Niko, T Haruta, T Imamura… - Scientific Reports, 2022 - nature.com
Insulin balls, localized insulin amyloids formed at the site of repeated insulin injections in
patients with diabetes, cause poor glycemic control and cytotoxicity. Our previous study has …

Near‐Infrared Squaraine Dyes as Bright Fluorescent Probes: A Structure–Activity Photophysical Investigation in Liposomes

G Renno, F Cardano, V Ilieva… - European Journal of …, 2022 - Wiley Online Library
The efficient investigation of biological membranes is a constant demand in chemical
biology. Several families of Near Infra‐Red (NIR) dyes have been already studied for the …