Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining
feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). In the majority of …

With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α …

Amyloids are a class of protein with unique self-aggregation properties, and their aberrant
accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases …

Parkinson's disease (PD) is a highly heterogeneous disorder, which probably consists of
multiple subtypes. Aggregation of misfolded alpha-synuclein and propagation of these …

The two main pathological hallmarks of Parkinson's disease are loss of dopamine neurons
in the substantia nigra pars compacta and proteinaceous amyloid fibrils composed mostly of …

The conversion of endogenous alpha-synuclein (asyn) to pathological asyn-enriched
aggregates is a hallmark of Parkinson's disease (PD). These inclusions can be detected in …

The classic view portrays Parkinson disease (PD) as a motor disorder resulting from loss of
substantia nigra pars compacta dopaminergic neurons. Multiple studies, however, describe …

Over 20 years ago, the synaptic protein α-synuclein was identified as the primary component
of the Lewy bodies (LBs) that are a sine qua non of Parkinson's disease (PD). Since that …

The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …