Neuroinflammation in Parkinson's disease–putative pathomechanisms and targets for disease-modification

A Grotemeyer, RL McFleder, J Wu… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is a progressive and debilitating chronic disease that affects more
than six million people worldwide, with rising prevalence. The hallmarks of PD are motor …

Nuclear factor-kappa B and Alzheimer disease, unifying genetic and environmental risk factors from cell to humans

SV Jones, I Kounatidis - Frontiers in immunology, 2017 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia, an eversible, progressive
disease that causes problems with memory, thinking, language, planning, and behavior …

Modeling Neurodegenerative Disorders in Drosophila melanogaster

H Bolus, K Crocker, G Boekhoff-Falk… - International Journal of …, 2020 - mdpi.com
Drosophila melanogaster provides a powerful genetic model system in which to investigate
the molecular mechanisms underlying neurodegenerative diseases. In this review, we …

Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice

EL Ma, AD Smith, N Desai, L Cheung… - Brain, behavior, and …, 2017 - Elsevier
Objectives Traumatic brain injury (TBI) has complex effects on the gastrointestinal tract that
are associated with TBI-related morbidity and mortality. We examined changes in mucosal …

Charting the genotype–phenotype map: lessons from the Drosophila melanogaster Genetic Reference Panel

TFC Mackay, W Huang - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Understanding the genetic architecture (causal molecular variants, their effects, and
frequencies) of quantitative traits is important for precision agriculture and medicine and …

The power of natural variation for model organism biology

AP Gasch, BA Payseur, JE Pool - Trends in Genetics, 2016 - cell.com
Genetic background effects have long been recognized and, in some cases studied, but they
are often viewed as a nuisance by molecular biologists. We suggest that genetic variation …

How to catch a smurf?–Ageing and beyond… In vivo assessment of intestinal permeability in multiple model organisms

RR Martins, AW McCracken, MJP Simons… - Bio …, 2018 - bio-protocol.org
Abstract The Smurf Assay (SA) was initially developed in the model organism Drosophila
melanogaster where a dramatic increase of intestinal permeability has been shown to occur …

Using Drosophila as an integrated model to study mild repetitive traumatic brain injury

A Barekat, A Gonzalez, RE Mauntz, RW Kotzebue… - Scientific reports, 2016 - nature.com
Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. In
addition, there has been a growing appreciation that even repetitive, milder forms of TBI …

Mammalian Models of Traumatic Brain Injury and a Place for Drosophila in TBI Research

EJ Shah, K Gurdziel, DM Ruden - Frontiers in neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI), caused by a sudden blow or jolt to the brain that disrupts normal
function, is an emerging health epidemic with∼ 2.5 million cases occurring annually in the …

Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila

B van Alphen, S Stewart, M Iwanaszko, F Xu, K Li… - PLoS …, 2022 - journals.plos.org
In traumatic brain injury (TBI), the initial injury phase is followed by a secondary phase that
contributes to neurodegeneration, yet the mechanisms leading to neuropathology in vivo …