[HTML][HTML] Neuropathic pain: from mechanisms to treatment

NB Finnerup, R Kuner, TS Jensen - Physiological reviews, 2020 - journals.physiology.org
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

The role of calcitonin gene–related peptide in peripheral and central pain mechanisms including migraine

S Iyengar, MH Ossipov, KW Johnson - Pain, 2017 - journals.lww.com
Calcitonin gene–related peptide (CGRP) is a 37-amino acid peptide found primarily in the C
and Aδ sensory fibers arising from the dorsal root and trigeminal ganglia, as well as the …

Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion

FA Pinho-Ribeiro, L Deng, DV Neel, O Erdogan… - Nature, 2023 - nature.com
The meninges are densely innervated by nociceptive sensory neurons that mediate pain
and headache,. Bacterial meningitis causes life-threatening infections of the meninges and …

Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain

J Kupari, D Usoskin, M Parisien, D Lou, Y Hu… - Nature …, 2021 - nature.com
Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …

Pulmonary neuroendocrine cells amplify allergic asthma responses

P Sui, DL Wiesner, J Xu, Y Zhang, J Lee, S Van Dyken… - Science, 2018 - science.org
INTRODUCTION The lung, with its vast surface area, senses and responds to signals in
inhaled air. Aberrant interactions between the lung and the environment underlie many …

Calcitonin gene-related peptide: physiology and pathophysiology

FA Russell, R King, SJ Smillie, X Kodji… - Physiological …, 2014 - journals.physiology.org
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30
years ago, it is produced as a consequence of alternative RNA processing of the calcitonin …

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

TS Jensen, NB Finnerup - The Lancet Neurology, 2014 - thelancet.com
Allodynia (pain due to a stimulus that does not usually provoke pain) and hyperalgesia
(increased pain from a stimulus that usually provokes pain) are prominent symptoms in …

Deconstructing the sensation of pain: The influence of cognitive processes on pain perception

K Wiech - Science, 2016 - science.org
Phenomena such as placebo analgesia or pain relief through distraction highlight the
powerful influence cognitive processes and learning mechanisms have on the way we …

Neural circuits for pain: recent advances and current views

C Peirs, RP Seal - Science, 2016 - science.org
The mammalian nervous system encodes many different forms of pain, from those that arise
as a result of short-term low-grade interactions with noxious thermal, chemical, or …

[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis

M Steinhoff, F Ahmad, A Pandey, A Datsi… - Journal of Allergy and …, 2022 - Elsevier
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …