Abstract βII spectrin, the most common isoform of non-erythrocyte spectrin, is a cytoskeleton
protein present in all nucleated cells. Interestingly, βII spectrin is essential for the …

Spectrins are cytoskeletal proteins that are expressed ubiquitously in the mammalian
nervous system. Pathogenic variants in SPTAN1, SPTBN1, SPTBN2 and SPTBN4, four of …

Hearing loss is one of the top contributors to years lived with disability and is a risk factor for
dementia. Molecular evidence on the cellular origins of hearing loss in humans is growing …

Age-related hearing impairment (ARHI) is the most common sensory impairment in the
aging population; a third of individuals are affected by disabling hearing loss by the age of …

The transport system in cochlear hair cells (HCs) is important for their function, and the
kinesin family of proteins transports numerous cellular cargos via the microtubule network in …

Waardenburg syndrome (WS), also known as auditory-pigmentary syndrome, is the most
common cause of syndromic hearing loss (HL), which accounts for approximately 2–5% of …

Sensory‐independent Ca2+ spiking regulates the development of mammalian sensory
systems. In the immature cochlea, inner hair cells (IHCs) fire spontaneous Ca2+ action …

The stria vascularis (SV) generates the endocochlear potential (EP) in the inner ear and is
necessary for proper hair cell (HC) mechanotransduction and hearing. Cell junctions are …

Noise overexposure leads to hair cell loss, synaptic ribbon reduction, and auditory nerve
deterioration, resulting in transient or permanent hearing loss depending on the exposure …

Cisplatin is a widely used chemotherapeutic agent for the treatment of various tumors, but its
side effects limit its application. Ototoxicity, a major adverse effect of cisplatin, causes …