Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective

K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Carbon monoxide toxicity

KA Nañagas, SJ Penfound… - Emergency Medicine …, 2022 - emed.theclinics.com
Carbon monoxide (CO) is an insidious poison that mimics a great number of other disease
processes. The clinical presentations associated with CO toxicity may be diverse and …

Carbon monoxide and the CNS: challenges and achievements

CSF Queiroga, A Vercelli… - British Journal of …, 2015 - Wiley Online Library
Haem oxygenase (HO) and its product carbon monoxide (CO) are associated with
cytoprotection and maintenance of homeostasis in several different organs and tissues. This …

Examining the antimicrobial activity and toxicity to animal cells of different types of CO-releasing molecules

LS Nobre, H Jeremias, CC Romão, LM Saraiva - Dalton Transactions, 2016 - pubs.rsc.org
Transition metal carbonyl complexes used as CO-releasing molecules (CORMs) for
biological and therapeutic applications may exhibit interesting antimicrobial activity …

[HTML][HTML] Carbon monoxide and a change of heart

LM Chu, S Shaefi, JD Byrne, RWA de Souza… - Redox biology, 2021 - Elsevier
The relationship between carbon monoxide and the heart has been extensively studied in
both clinical and preclinical settings. The Food and Drug Administration (FDA) is keenly …

Inhibition of iNOS alleviates cognitive deficits and depression in diabetic mice through downregulating the NO/sGC/cGMP/PKG signal pathway

X yan Zhou, F Zhang, C jiang Ying, J Chen… - Behavioural Brain …, 2017 - Elsevier
Diabetes mellitus often results in a number of complications involving impaired brain
function, including cognitive deficits and depression. However, the potential mechanisms for …

Carbon monoxide stimulates both mitophagy and mitochondrial biogenesis to mediate protection against oxidative stress in astrocytes

C Figueiredo-Pereira, B Villarejo-Zori… - Molecular …, 2023 - Springer
Astrocytes are key glial cells for the metabolic and functional support of the brain.
Mitochondrial quality control (MQC), in particular the balance between mitophagy and …

Carbon monoxide-releasing molecule-3 protects against cortical pyroptosis induced by hemorrhagic shock and resuscitation via mitochondrial regulation

LM Zhang, DX Zhang, L Fu, Y Li, XP Wang… - Free Radical Biology …, 2019 - Elsevier
Objective Carbon monoxide (CO) releasing molecule (CORM)-3, a water-soluble CORM,
has protective effects against inflammatory and ischemia/reperfusion injury. We determined …

An overview of the potential therapeutic applications of CO‐releasing molecules

A Ismailova, D Kuter, DS Bohle… - Bioinorganic Chemistry …, 2018 - Wiley Online Library
Carbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form
carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an …

Carbon monoxide signaling and soluble guanylyl cyclase: Facts, myths, and intriguing possibilities

W Lu, X Yang, B Wang - Biochemical pharmacology, 2022 - Elsevier
The endogenous signaling roles of carbon monoxide (CO) have been firmly established at
the pathway level. For CO's molecular mechanism (s) of actions, hemoproteins are generally …