Circadian rhythms in neurodegenerative disorders
M Nassan, A Videnovic - Nature Reviews Neurology, 2022 - nature.com
Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …
circadian rhythms that synchronize physiological and behavioural functions in humans. The …
[HTML][HTML] Is dysregulation of the HPA-axis a core pathophysiology mediating co-morbid depression in neurodegenerative diseases?
There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …
Timed light therapy for sleep and daytime sleepiness associated with Parkinson disease: a randomized clinical trial
Importance Impaired sleep and alertness are some of the most common nonmotor
manifestations of Parkinson disease (PD) and currently have only limited treatment options …
manifestations of Parkinson disease (PD) and currently have only limited treatment options …
[HTML][HTML] Circadian rhythm sleep–wake disorders: a contemporary review of neurobiology, treatment, and dysregulation in neurodegenerative disease
Circadian rhythms oscillate throughout a 24-h period and impact many physiological
processes and aspects of daily life, including feeding behaviors, regulation of the sleep …
processes and aspects of daily life, including feeding behaviors, regulation of the sleep …
Treating the whole body in Huntington's disease
Huntington's disease is a genetic neurodegenerative disorder with symptoms that are linked
to the progressive dysfunction and neuronal death in corticostriatal circuits. The causative …
to the progressive dysfunction and neuronal death in corticostriatal circuits. The causative …
[HTML][HTML] The translational benefits of sheep as large animal models of human neurological disorders
SJ Murray, NL Mitchell - Frontiers in Veterinary Science, 2022 - frontiersin.org
The past two decades have seen a considerable rise in the use of sheep to model human
neurological disorders. While each animal model has its merits, sheep have many …
neurological disorders. While each animal model has its merits, sheep have many …
A review of fundamental principles for animal models of DOHaD research: an Australian perspective
Epidemiology formed the basis of 'the Barker hypothesis', the concept of 'developmental
programming'and today's discipline of the Developmental Origins of Health and Disease …
programming'and today's discipline of the Developmental Origins of Health and Disease …
Artificial miRNAs reduce human mutant Huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease
EL Pfister, N DiNardo, E Mondo, F Borel… - Human gene …, 2018 - liebertpub.com
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a genetic
expansion of the CAG repeat region in the huntingtin (HTT) gene. Studies in HD mouse …
expansion of the CAG repeat region in the huntingtin (HTT) gene. Studies in HD mouse …
Sheep recognize familiar and unfamiliar human faces from two-dimensional images
F Knolle, RP Goncalves… - Royal Society Open …, 2017 - royalsocietypublishing.org
One of the most important human social skills is the ability to recognize faces. Humans
recognize familiar faces easily, and can learn to identify unfamiliar faces from repeatedly …
recognize familiar faces easily, and can learn to identify unfamiliar faces from repeatedly …
Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases
RR Handley, SJ Reid, R Brauning… - Proceedings of the …, 2017 - National Acad Sciences
The neurodegenerative disorder Huntington's disease (HD) is typically characterized by
extensive loss of striatal neurons and the midlife onset of debilitating and progressive …
extensive loss of striatal neurons and the midlife onset of debilitating and progressive …