[HTML][HTML] Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?

CD Correia, A Ferreira, MT Fernandes, BM Silva… - Cells, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are pointed out by the World Health Organization (WHO)
as the leading cause of death, contributing to a significant and growing global health and …

[HTML][HTML] Healing the broken heart; the immunomodulatory effects of stem cell therapy

MJ Wagner, M Khan, S Mohsin - Frontiers in Immunology, 2020 - frontiersin.org
Cardiovascular Disease (CVD) is a leading cause of mortality within the United States.
Current treatments being administered to patients who suffered a myocardial infarction (MI) …

Expansion and characterization of neonatal cardiac pericytes provides a novel cellular option for tissue engineering in congenital heart disease

E Avolio, I Rodriguez‐Arabaolaza… - Journal of the …, 2015 - Am Heart Assoc
Background Living grafts produced by combining autologous heart‐resident stem/progenitor
cells and tissue engineering could provide a new therapeutic option for definitive correction …

Mesenchymal stem cells preserve neonatal right ventricular function in a porcine model of pressure overload

B Wehman, S Sharma, N Pietris… - American Journal …, 2016 - journals.physiology.org
Limited therapies exist for patients with congenital heart disease (CHD) who develop right
ventricular (RV) dysfunction. Bone marrow-derived mesenchymal stem cells (MSCs) have …

Study design and rationale for ELPIS: A phase I/IIb randomized pilot study of allogeneic human mesenchymal stem cell injection in patients with hypoplastic left heart …

S Kaushal, B Wehman, N Pietris, C Naughton… - American heart …, 2017 - Elsevier
Despite advances in surgical technique and postoperative care, long-term survival of
children born with hypoplastic left heart syndrome (HLHS) remains limited, with cardiac …

[PDF][PDF] Comparative efficacy and mechanism of action of cardiac progenitor cells after cardiac injury

M Gunasekaran, R Mishra, P Saha, D Morales… - Iscience, 2022 - cell.com
Successful cell therapy requires cells to resist the hostile ischemic myocardium, be retained
to continue secreting cardioprotective growth factors/exosomes, and resist immunological …

[HTML][HTML] Amniotic fluid mesenchymal stromal cells derived from fetuses with isolated cardiac defects exhibit decreased proliferation and cardiomyogenic potential

M Jain, N Singh, R Fatima, A Nachanekar, M Pradhan… - Biology, 2023 - mdpi.com
Simple Summary Congenital heart defect (CHD) is the most common birth defect that affects
the structure of the heart from birth. A possible reason for this occurrence could be …

Cell therapy trials in congenital heart disease

H Oh - Circulation research, 2017 - Am Heart Assoc
Dramatic evolution in medical and catheter interventions and complex surgeries to treat
children with congenital heart disease (CHD) has led to a growing number of patients with a …

In Vitro and In Vivo Preclinical Testing of Pericyte‐Engineered Grafts for the Correction of Congenital Heart Defects

VV Alvino, M Kilcooley, AC Thomas… - Journal of the …, 2020 - Am Heart Assoc
Background We have previously reported the possibility of using pericytes from leftovers of
palliative surgery of congenital heart disease to engineer clinically certified prosthetic grafts …

[HTML][HTML] Establishment of a protocol to administer immunosuppressive drugs for iPS cell-derived cardiomyocyte patch transplantation in a rat myocardial infarction …

E Ito, A Kawamura, T Kawamura, M Takeda… - Scientific Reports, 2023 - nature.com
Transplantation of human allogeneic induced pluripotent stem cell-derived cardiomyocytes
(hiPSC-CMs) is a new, promising treatment for severe heart failure. However …