Positive, prosocial interactions are essential for survival, development, and well-being.
These intricate and complex behaviors are mediated by an amalgamation of neural circuit …

Background Autism spectrum disorder (ASD) is a neurodevelopmental condition, which is
characterized by clinical heterogeneity and high heritability. Core symptoms of ASD include …

Among the brainstem raphe nuclei, the dorsal raphe nucleus (DR) contains the greatest
number of Pet1-lineage neurons, a predominantly serotonergic group distributed throughout …

Major depressive disorder (MDD) is one of the most common and disabling mental
disorders, and current strategies remain inadequate. Although mesenchymal stromal cells …

Alzheimer's disease (AD) poses an ever-increasing public health concern as the population
ages, affecting more than 6 million Americans. AD patients present with mood and sleep …

The brain serotonin systems participate in numerous aspects of reward processing, although
it remains elusive how exactly serotonin signals regulate neural computation and reward …

Changing serotonin (5-hydroxytryptamine, 5-HT) brain levels during critical periods in
development has long-lasting effects on brain function, particularly on later …

Phelan–McDermid syndrome (PMS) is a rare genetic disorder in which one copy of the
SHANK3 gene is missing or mutated, leading to a global developmental delay, intellectual …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects one in 66
children in Canada. The contributions of changes in the cortex and cerebellum to autism …

Adolescent alcohol use can permanently alter brain function and lead to poor health
outcomes in adulthood. Emerging evidence suggests that alcohol use can predispose …