Reducing the off-target endocrinologic adverse effects of azole antifungals—can it be done?
MI Balcerek, AG Stewart, P Chapman… - International Journal of …, 2022 - Elsevier
Azoles are among the most effective and widely used class of antifungals for prophylaxis as
well as empirical and directed therapy against yeast and mould infections. Their use …
well as empirical and directed therapy against yeast and mould infections. Their use …
[HTML][HTML] Case Report: Hypercalcemia as a manifestation of acute adrenal crisis precipitated by fluconazole use, and a review of the literature
KS Choo, J Yew, EJH Tan, THK Puar - Frontiers in Endocrinology, 2023 - frontiersin.org
Acute adrenal crisis classically presents with vomiting, altered sensorium, and hypotension.
We describe a unique case manifesting with severe hypercalcemia. Addisonian crisis was …
We describe a unique case manifesting with severe hypercalcemia. Addisonian crisis was …
[HTML][HTML] Characterization of the interferences of systemic azole antifungal drugs with adrenal steroid biosynthesis using H295R cells and enzyme activity assays
MC Jäger, FL Joos, DV Winter, A Odermatt - Current Research in …, 2023 - Elsevier
Azole antifungals, designed to inhibit fungal CYP51, have a liability to inhibit human CYP
enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment …
enzymes. Whilst drug-metabolizing CYPs are covered in preclinical safety assessment …
Posaconazole-induced primary adrenal insufficiency: A rare but real risk
A Precali, P Roncevic, I Kraljevic - Annales d'Endocrinologie, 2024 - Elsevier
Primary adrenal insufficiency (PAI) consists in a lack of adrenal hormones, and particularly
of cortisol and aldosterone. It typically presents with fatigue, weakness, loss of appetite …
of cortisol and aldosterone. It typically presents with fatigue, weakness, loss of appetite …