Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …
Clinical evidence indicates that the fatal outcome observed with severe acute respiratory
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
syndrome-coronavirus-2 infection often results from alveolar injury that impedes airway …
Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages
L Chávez-Galán, ML Olleros, D Vesin… - Frontiers in …, 2015 - frontiersin.org
Monocytes are considered to be precursor cells of the mononuclear phagocytic system, and
macrophages are one of the leading members of this cellular system. Macrophages play …
macrophages are one of the leading members of this cellular system. Macrophages play …
Tissue-resident macrophages
Tissue-resident macrophages are a heterogeneous population of immune cells that fulfill
tissue-specific and niche-specific functions. These range from dedicated homeostatic …
tissue-specific and niche-specific functions. These range from dedicated homeostatic …
Regulation of antiviral T cell responses by type I interferons
Type I interferons (IFNs) are pro-inflammatory cytokines that are rapidly induced in different
cell types during viral infections. The consequences of type I IFN signalling include direct …
cell types during viral infections. The consequences of type I IFN signalling include direct …
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across
AK Minnaert, H Vanluchene, R Verbeke… - Advanced drug delivery …, 2021 - Elsevier
The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-
2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA …
2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA …
The mannose receptor
L Martinez-Pomares - Journal of leukocyte biology, 2012 - academic.oup.com
Review on mannose receptor as an endocytic receptor in antigen delivery that is co-
expressed with the microRNA miR-511-3p encoded within the Mrc1 gene. The MR is a …
expressed with the microRNA miR-511-3p encoded within the Mrc1 gene. The MR is a …
Perivascular macrophages in health and disease
A Lapenna, M De Palma, CE Lewis - Nature Reviews Immunology, 2018 - nature.com
Macrophages are a heterogeneous group of cells that are capable of carrying out distinct
functions in different tissues, as well as in different locations within a given tissue. Some of …
functions in different tissues, as well as in different locations within a given tissue. Some of …
Type I interferons in viral control and immune regulation
JR Teijaro - Current opinion in virology, 2016 - Elsevier
Highlights•IFN-I signaling has recently been shown to contribute to viral immune
pathologies.•Elevated IFN-I signatures are found in persistent virus infections in multiple …
pathologies.•Elevated IFN-I signatures are found in persistent virus infections in multiple …
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
J Hou, L Han, Z Zhao, H Liu, L Zhang, C Ma… - Nature …, 2021 - nature.com
Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is
indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS …
indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS …