Shigellosis is a clinical syndrome caused by invasion of the epithelium lining the terminal
ileum, colon, and rectum by Shigella species. Although infections occur globally, and in …

Shigella is the leading cause of global diarrheal deaths that currently lacks a licensed
vaccine. Shigellosis drives antimicrobial resistance and leads to economic impact through …

Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development |
Clinical Infectious Diseases | Oxford Academic Skip to Main Content Advertisement Oxford …

Recent technological advances in glycobiology and glycochemistry are paving the way for a
new era in carbohydrate vaccine design. This is enabling greater efficiency in the …

Few studies provide data on the global morbidity and mortality caused by infection with
Shigella spp.; such estimates are needed, however, to plan strategies of prevention and …

Shigellosis is a global human health problem. Four species of Shigella ie S. dysenteriae, S.
flexneri, S. boydii and S. sonnei are able to cause the disease. These species are …

Enteric infections, with or without overt diarrhea, have profound effects on intestinal
absorption, nutrition, and childhood development as well as on global mortality. Oral …

Background The burden of shigellosis is greatest in resource-poor countries. Although this
diarrheal disease has been thought to cause considerable morbidity and mortality in excess …

Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …

Background Shigellosis is a major cause of moderate to severe diarrhoea and dysentery in
children under 5 years of age in low and middle-income countries. The Flexyn2a vaccine …