The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

The digestive tract plays a central role in the digestion and absorption of nutrients. Far from
being a passive tube, it provides the first line of defense against pathogens and maintains …

Copper (Cu) is an essential micronutrient required for the activity of redox‐active enzymes
involved in critical metabolic reactions, signaling pathways, and biological functions …

Each year ecotoxicological problems become increasingly complex and encompass
broader spatial and temporal scales. Our practical understanding must evolve accordingly to …

Research advances defining how zinc is transported into and out of cells and organelles
have increased exponentially within the past five years. Research has progressed through …

The metal-responsive transcription factor-1 (MTF-1, also termed MRE-binding transcription
factor-1 or metal regulatory transcription factor-1) is a pluripotent transcriptional regulator …

The biological effects of environmental metal contamination are important issues in an
industrialized, resource-dependent world. Different metals have different roles in biology …

The CRR1 (Copper Response Regulator) locus, required for both activating and repressing
target genes of a copper-and hypoxia-sensing pathway in Chlamydomonas, encodes a …

Zinc metabolism in higher eukaryotes is complex, being controlled by uptake, efflux, and
storage in individual cells, as well as in peripheral tissues and organs. Recently there have …

Iron, copper, and zinc are all essential nutrients. The electron transfer properties of iron and
copper are fundamental to processes such as respiration and photosynthesis. Zinc forms the …