The beneficial effects of physical activity on brain ageing are well recognised, with
exerkines, factors that are secreted into the circulation in response to exercise, emerging as …

Physical activity is a strong positive physiological modulator of adult neurogenesis in the
hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still …

Chromatin modifiers act to coordinate gene expression changes critical to neuronal
differentiation from neural stem/progenitor cells (NSPCs). Lysine-specific methyltransferase …

The developing nervous system is highly vulnerable to environmental toxicants especially
pesticides. Glyphosate pesticide induces neurotoxicity both in humans and rodents, but so …

L-lactate has energetic and signaling properties, and its availability is modulated by activity-
dependent stimuli, which also regulate adult hippocampal neurogenesis. Studying the …

Intensive agriculture activities, industrialization and growing numbers of wastewater
treatment plants along river banks collectively contribute to the elevated levels of neurotoxic …

The mild hypothermia response (MHR) maintains organismal homeostasis during cold
exposure and is thought to be critical for the neuroprotection documented with therapeutic …

Troxerutin (TRX) is a water-soluble flavonoid which occurs commonly in the edible plants.
Recent studies state that TRX improves the functionality of the nervous system and …

Physical exercise has well-established anti-inflammatory effects, with neuro-immunological
crosstalk being proposed as a mechanism underlying the beneficial effects of exercise on …

Wiedemann-Steiner syndrome (WDSTS) is a rare genetic cause of intellectual disability
primarily caused by heterozygous loss of function variants in the gene encoding the histone …