[HTML][HTML] Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
O Leiter, D Brici, SJ Fletcher, XLH Yong… - Nature …, 2023 - nature.com
The beneficial effects of physical activity on brain ageing are well recognised, with
exerkines, factors that are secreted into the circulation in response to exercise, emerging as …
exerkines, factors that are secreted into the circulation in response to exercise, emerging as …
[HTML][HTML] Exercise-induced activated platelets increase adult hippocampal precursor proliferation and promote neuronal differentiation
O Leiter, S Seidemann, RW Overall, B Ramasz… - Stem cell reports, 2019 - cell.com
Physical activity is a strong positive physiological modulator of adult neurogenesis in the
hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still …
hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still …
[HTML][HTML] Precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome
Chromatin modifiers act to coordinate gene expression changes critical to neuronal
differentiation from neural stem/progenitor cells (NSPCs). Lysine-specific methyltransferase …
differentiation from neural stem/progenitor cells (NSPCs). Lysine-specific methyltransferase …
Environment permissible concentrations of glyphosate in drinking water can influence the fate of neural stem cells from the subventricular zone of the postnatal mouse
The developing nervous system is highly vulnerable to environmental toxicants especially
pesticides. Glyphosate pesticide induces neurotoxicity both in humans and rodents, but so …
pesticides. Glyphosate pesticide induces neurotoxicity both in humans and rodents, but so …
[HTML][HTML] L-lactate exerts a pro-proliferative effect on adult hippocampal precursor cells in vitro
L-lactate has energetic and signaling properties, and its availability is modulated by activity-
dependent stimuli, which also regulate adult hippocampal neurogenesis. Studying the …
dependent stimuli, which also regulate adult hippocampal neurogenesis. Studying the …
Neural stem cell-based in vitro bioassay for the assessment of neurotoxic potential of water samples
Intensive agriculture activities, industrialization and growing numbers of wastewater
treatment plants along river banks collectively contribute to the elevated levels of neurotoxic …
treatment plants along river banks collectively contribute to the elevated levels of neurotoxic …
[HTML][HTML] SMYD5 is a regulator of the mild hypothermia response
S Rafnsdottir, K Jang, ST Halldorsdottir, M Vinod… - Cell Reports, 2024 - cell.com
The mild hypothermia response (MHR) maintains organismal homeostasis during cold
exposure and is thought to be critical for the neuroprotection documented with therapeutic …
exposure and is thought to be critical for the neuroprotection documented with therapeutic …
[HTML][HTML] Troxerutin flavonoid has neuroprotective properties and increases neurite outgrowth and migration of neural stem cells from the subventricular zone
Troxerutin (TRX) is a water-soluble flavonoid which occurs commonly in the edible plants.
Recent studies state that TRX improves the functionality of the nervous system and …
Recent studies state that TRX improves the functionality of the nervous system and …
[HTML][HTML] The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation
Physical exercise has well-established anti-inflammatory effects, with neuro-immunological
crosstalk being proposed as a mechanism underlying the beneficial effects of exercise on …
crosstalk being proposed as a mechanism underlying the beneficial effects of exercise on …
In-utero rescue of neurological dysfunction in a mouse model of Wiedemann-Steiner syndrome
T Reynisdottir, KJ Anderson, A Brinn, K Franklin… - bioRxiv, 2024 - biorxiv.org
Wiedemann-Steiner syndrome (WDSTS) is a rare genetic cause of intellectual disability
primarily caused by heterozygous loss of function variants in the gene encoding the histone …
primarily caused by heterozygous loss of function variants in the gene encoding the histone …